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Results: 2

1.
Scheme 1

Scheme 1. From: Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.

Bcl-XL-templated assembly of acylsulfonamide SZ4TA2 from fragments decorated with thio acid or sulfonyl azide functionalities.

Xiangdong Hu, et al. J Am Chem Soc. ;130(42):13820-13821.
2.
Figure 1

Figure 1. From: Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.

Hit identification of acylsulfonamide SZ4TA2 by LC/MS-SIM. (A) Incubation of SZ4 and TA2 in buffer without Bcl-XL. (B) Bcl-XL-templated reaction after 6 hours of incubation. (C) Synthesized SZ4TA2 as reference. (D) Suppression of Bcl-XL-templated reaction by Bak BH3 peptide. (E) Bcl-XL-templated incubation in presence of mutant Bak BH3 peptide. (F) Suppression of Bcl-XL-templated reaction by Bim BH3 peptide. (G) Bcl-XL-templated incubation in presence of mutant Bim BH3 peptide.

Xiangdong Hu, et al. J Am Chem Soc. ;130(42):13820-13821.

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