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Results: 8

1.
Figure 8.

Figure 8. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

Kaplan-Meier analysis of cumulative renal survival between nonprogressive group (grades I and II; n = 151) and progressive group (grades III and IV; n = 177) of patients with IgAN. χ2 = 52.014, P < 0.0001.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
2.
Figure 4.

Figure 4. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

(A) The transcript levels of TLR9 correlated with those of MyD88 in conventional group mice with severe GN (regression analysis; n = 20; P < 0.0001). (B and C) In these mice, transcript levels of TLR9 were associated with the degree of urinary albumin as well as levels of serum IgA (P < 0.001 and P < 0.01, respectively). Transcript levels of TLR9 and MyD88 were standardized relative to GAPDH.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
3.
Figure 2.

Figure 2. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

Changes of serum IgA, IgG, and IgM levels in the conventional and SPF groups. Although the mean IgA levels increased with age in both groups, IgA levels in the conventional group were higher than those in the SPF group at 30 to 50 wk of age. •, conventional group; □, SPF group. Data are means ± SD. *P < 0.05.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
4.
Figure 7.

Figure 7. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

Levels of cytokines produced by splenic T cells after treatment with CpG-ODN. After treatment with CpG-ODN, the level of IFN-γ in culture supernatant of spleen cells was elevated. Data are means ± SD. **P < 0.01. CpG, early-onset mice in the SPF group treated with CpG-ODN (n = 10); non-CpG, early-onset ddY mice of the SPF group treated with CpG-ODN (n = 10); control, untreated early-onset ddY mice of the SPF group (n = 10).

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
5.
Figure 1.

Figure 1. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

Susceptibility locus for the progression of renal injury on murine chromosome 9. Solid line at χ2 = 14.4 indicates the significant threshold, and the lower dotted line at χ2 = 10.0 indicates the suggestive thresholds, which were calculated by permutation analysis. On chromosome 9, the maximal χ2 value was 21.103 (P = 0.00017, genome-wide significant P = 0.0027) at the D9MIT216 marker locus, which lies in very close proximity to the MyD88 gene. The flanking markers of peak and their positions are shown in the inset.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
6.
Figure 5.

Figure 5. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

Levels of cytokines produced by splenic T cells. Levels of IFN-γ in culture supernatants of spleen cells from mice with commencing IgAN in the conventional group (n = 10) were higher than those in the SPF group (n = 10), although levels of IL-4 did not change between those two groups. Data are means ± SD. **P < 0.01. Age-matched quiescent ddY mice (n = 10) and BALB/c mice (n = 10) showed low production of IFN-γ and high production of IL-4 compared with the ddY mice with commencing IgAN.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
7.
Figure 3.

Figure 3. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

(A) Splenic transcriptional levels of TLR quantified by real-time RT-PCR in mice with renal injuries at 60 wk of age. Levels of TLR9 and MyD88 transcription in the conventional group (n = 20) were higher than those in the SPF group (n = 20). The quiescent mice in both groups were used for controls (each n = 10). Transcriptional levels of TLR2 and TLR4 did not show any differences among the groups. (B) The ddY mice with commencing IgAN were divided into severe GN (n = 10) and mild GN (n = 10) groups by the severity of renal injuries. Levels of TLR9 and MyD88 transcriptions were elevated in mice with severe GN. •, conventional group; ○, SPF group. Each circle shows individual datum standardized as a ratio of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) transcription. Data are means ± SD. *P < 0.05; **P < 0.01.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.
8.
Figure 6.

Figure 6. From: Toll-Like Receptor 9 Affects Severity of IgA Nephropathy.

(A) Evaluation of renal injuries by semiquantitative scoring after challenge with CpG-ODN. The ddY mice with commencing IgAN in the SPF group were treated with CpG-ODN (n = 10) or non–CpG-ODN (n = 10). Untreated ddY mice with commencing IgAN were evaluated as control (n = 10). Renal injuries in mice challenged with CpG-ODN were exacerbated. The degree of renal injuries in mice treated with non–CpG-ODN was similar to those in control. (B) CpG-ODN enhanced the degree of urinary albumin. (C) Intensity of glomerular IgA deposition was evaluated semiquantitatively. There was a tendency for the intensity of glomerular IgA deposition to increase after treatment with CpG-ODN. (D) Serum levels of IgA and IgG were elevated in the mice treated with CpG-ODN. (E) Serum levels of IgA-IgG2a IC expressed relative to those of BALB/c mice. CpG-ODN increased serum IgA-IgG2a IC levels. (F) Transcript levels of TLR9 and MyD88 were quantified by real-time RT-PCR. Levels of TLR9 and MyD88 transcription were enhanced by treatment with CpG-ODN. Data are means ± SD. *P < 0.05; **P < 0.01. CpG, mice immunized with CpG-ODN; non-CpG, mice immunized with non–CpG-ODN; control, age-matched ddY mice with commencing IgAN without immunization.

Hitoshi Suzuki, et al. J Am Soc Nephrol. 2008 December;19(12):2384-2395.

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