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1.
Figure 1

Figure 1. From: Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele.

The association between proline and SPEM is moderated by the COMT158 genotype. Only in the COMTmet subgroup a decreased SPEM performance was associated with high plasma proline levels in 22q11DS individuals (p = 0.028), whereas in the COMTval group no significant difference was revealed between the high/low proline subgroups (p = 0.827). Proline levels were not available in seven subjects; therefore the sample size in this analysis is 49.

Jacob AS Vorstman, et al. Neuropsychopharmacology. ;34(3):739-746.
2.
Figure 2

Figure 2. From: Proline Affects Brain Function in 22q11DS Children with the Low Activity COMT158 Allele.

Schematic representation of the hypothesized model. High proline levels induce glutamatergic signaling in the hippocampus. Increased glutamatergic tone causes a release of DA in the PFC. In 22q11DS subjects hemizygous for COMTmet (in blue), the inefficiency in catabolizing DA leads to a large shift to the right (dotted line). This, in combination with a starting position somewhat right of the curve’s optimum, leads to a decrease in PFC function. In those hemizygous for COMTval (in red), excess DA can be more adequately catabolized; the resulting shift, if any, on the hypothetical model of the inverted U-shaped curve is more moderate and does not result in a substantial change in PFC function (inverted U-shape curve adapted from Mattay et al, 2003).

Jacob AS Vorstman, et al. Neuropsychopharmacology. ;34(3):739-746.

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