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Results: 6

1.
Figure 1

Figure 1. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

Generating “whole mount” gene expression maps using the tissue print micropeel technique.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.
2.
Figure 4

Figure 4. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

An immunofluorescence stained section showing NPY (middle) taken from the bottom-middle section of the gland shown in Figure 2. The phase-contrast image is shown on the left. The DAPI stain is shown on the right.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.
3.
Figure 6

Figure 6. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

Contrasting Patterns of Tumor Microvasculature in the Prostate Cancers Shown in Figure 3 and Figure 5. CD34 IHC staining was used to visualize tumor microvessels. An image analysis “atlas” of the microvessel elements highlight the difference between these two cancers, with the more uniform pattern evident in the Figure 3 tumor being characteristic of a more “mature” tumor vasculature.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.
4.
Figure 2

Figure 2. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

Spatial overlay maps showing results of RNA microarray and rt-PCR analysis for AMACR, Choline kinase, NPY and VEGF. The color-coded maps derived from the analysis of DCEMRI as well as the histopathology (H and E stain) are shown for spatial reference. Note the two solid circles indicated in the tissue print grid that show the regions used for microarray analysis.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.
5.
Figure 3

Figure 3. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

Immunohistochemical stains obtained using horseradish peroxidase readout of sections taken from the bottom-middle section of the gland shown in Figure 2 as indicated above in the stained sections. The tumor is outlined in black, a region showing chronic inflammatory changes is shown in green. Note that these images are shown in the pathologist’s convention (real left, right), whereas the images shown in Figure 2 are shown in the radiology convention, (patient left, right). The subjective intensity of the stain is greatest for NPY and least for VEGF; these visual impressions were confirmed by automated image analysis.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.
6.
Figure 5

Figure 5. From: Mapping MRI/MRS Parameters with Genetic Over-expression Profiles In Human Prostate Cancer: Demonstrating the Potential.

Immunohistochemical stains obtained using horseradish peroxidase readout of the prostate of a patient with proven prostate cancer. The tumor is outlined in blue of the H and E stain in the series of low magnification images showing an entire slice of the gland. The color-coded image obtained from an analysis of the non-invasive DCEMRI sequence is shown on the left. The red region indicated by the white arrow is the tumor. The yellow arrows are showing two BPH nodules adjacent to the tumor. The intensity of VEGF and NPY expression shown in the high magnification images reflects the same conditions of IHC staining as shown in the high magnification images in Figure 3.

Robert E. Lenkinski, et al. MAGMA. ;21(6):411-421.

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