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Results: 5

1.
Fig. 2

Fig. 2. From: Point: The linear-quadratic model is an appropriate methodology for determining iso-effective doses at large doses per fraction.

Survival of x-irradiated CHO cells, determined by flow cytometry population counting, five days after treatment (22). The curve is the corresponding LQ model ft.

David J. Brenner. Semin Radiat Oncol. ;18(4):234-239.
2.
Fig. 5

Fig. 5. From: Point: The linear-quadratic model is an appropriate methodology for determining iso-effective doses at large doses per fraction.

For a single acute dose fraction, shown is the percent relative difference [100(SSR-SLQ)/SSR] between survival calculated exactly using the SR model and survival calculated using the corresponding LQ approximation. Calculations reported in Ref (32), based on the parameter set from Kiefer and Löbrich (45).

David J. Brenner. Semin Radiat Oncol. ;18(4):234-239.
3.
Fig. 4

Fig. 4. From: Point: The linear-quadratic model is an appropriate methodology for determining iso-effective doses at large doses per fraction.

Isoeffect data for late response from three (□○Δ) different regions of the rat spinal cord (25), for acute skin reactions (◆) in mice (26), and for early (●) and late (⊕) murine intestinal damage (27). The data are plotted in a “reciprocal-dose Fe” form (26) such that, if they follow a linear-quadratic relationship, the points fall on a straight line.

David J. Brenner. Semin Radiat Oncol. ;18(4):234-239.
4.
Fig. 3

Fig. 3. From: Point: The linear-quadratic model is an appropriate methodology for determining iso-effective doses at large doses per fraction.

Goodness of fit of LQ model to measured cell survival data, as a function of the dose range which was fitted (23). The quantity plotted is χ2 per degree of freedom, hence smaller values represent better fits to the LQ model. For example the left-most point represents a good fit of the LQ model to cell-survival data in the dose range from 0 Gy to 4 Gy, and the right-most point represents a less good fit of the LQ model to cell-survival data in the dose range from 0 Gy to 16 Gy.

David J. Brenner. Semin Radiat Oncol. ;18(4):234-239.
5.
Fig. 1

Fig. 1. From: Point: The linear-quadratic model is an appropriate methodology for determining iso-effective doses at large doses per fraction.

Examples of binary misrepair: 1A shows two chromosomes; each has one double strand break (DSB), shown as a gap. Centromeres, which are needed for proper transmission of chromosomes to daughter cells at mitosis, are shown as black constrictions. Most DSB are correctly restituted, but a few undergo binary misrepair. As shown in 1B, binary misrepair can result in a dicentric chromosome aberration, which generally destroys the clonogenic viability of the cell. In about half the binary misrepair events, the two DSB shown in Fig 1A lead to a translocation, shown in 1C; translocations involve large scale rearrangements, and can cause potentially precarcinogenic alterations in cellular phenotype, but most do not impair cellular survival.

David J. Brenner. Semin Radiat Oncol. ;18(4):234-239.

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