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1.
Figure 4

Figure 4. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

Correlations between plasma and brain glutamine levels

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
2.
Figure 6

Figure 6. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

Osmotic index is indicated by ratio of mI divided by total osmolytes (gln + mI).

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
3.
Figure 3

Figure 3. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

a–c: Disease severity and metabolite trends for several brain regions studied

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
4.
Figure 5

Figure 5. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

This figure shows the inverse relationship between brain gln and mI in subjects with OTCD but not controls, implicating impaired osmoregulation.

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
5.
Figure 2

Figure 2. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

a–e: These bar graphs demonstrate the concentrations of the major measured metabolites in brain in subjects and controls. Regions of significance between subjects carrying a mutation in the OTCD gene and controls is shown as a P value

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
6.
Figure 7

Figure 7. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

This overlapping spectrum obtained from the parietal white matter in a subject and age matched control illustrates differences in the concentration of several key metabolites.

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.
7.
Figure 1

Figure 1. From: 1H MRS identifies symptomatic and asymptomatic subjects with partial ornithine transcarbamylase deficiency.

Depiction of voxel locations from which metabolism was sampled: a) PWM= parietal white matter ; b) PCGM= posterior cingulate gray matter; c) tha= thalamus; d) FWM= frontal white matter; e) FGM= frontal gray matter.

A. L. Gropman, et al. Mol Genet Metab. ;95(0):21-30.

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