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Results: 2

1.
Figure 1

Figure 1. From: Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.

Q-Q plot of Kaplan-Meier P values for 89 genetic variants. Observed log-rank P values for individual Kaplan-Meier analyses are plotted against random expectations under the null hypothesis of no effect.

Thomas M Morgan, et al. BMC Med Genet. 2008;9:66-66.
2.
Figure 2

Figure 2. From: Investigation of 89 candidate gene variants for effects on all-cause mortality following acute coronary syndrome.

Mean P value differences (observed-random) in 50,000 simulations. The right panel shows a skewed distribution of simulated random minus actual Kaplan-Meier log-rank P values (N = 89), indicating that observed P values collectively were lower than expected. With the removal of 16 positive associations (P < 0.1), the remaining genetic variables closely approximated a random distribution, as shown in the left panel.

Thomas M Morgan, et al. BMC Med Genet. 2008;9:66-66.

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