Results: 4

1.
Figure 3

Figure 3. Immunoglobulin A (IgA) and polymeric immunogloblin receptor (pIgR) in the nasal passages. From: Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels.

Nasal passage lavage (a) and nasal passage homogenate (c) IgA levels were significantly decreased in parenteral nutrition (PN) groups. Nasal passage homogenate pIgR levels (b) did not change with PN treatment. Two bands ∼120 (pIgR) and ∼94 (secretory component) kDa were detected by Western blot (b). Values are expressed as mean ± SE. *p<0.05 vs. Chow.

Yoshifumi Sano, et al. J Surg Res. ;149(2):236-242.
2.
Figure 2

Figure 2. Immunoglobulin A (IgA) and polymeric immunoglobulin receptor (pIgR) in the small intestine. From: Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels.

Parentreral nutrition (PN) fed mice displayed significantly decreased small intestinal lavage IgA (a) and small intestinal homogenate pIgR (b) levels. There was no significant difference in small intestinal homogenate IgA levels (c). Two bands ∼120 (pIgR) and ∼94 (secretory component) kDa were detected by Western blot (b). Values are expressed as mean ± SE. *p<0.05 vs. Chow.

Yoshifumi Sano, et al. J Surg Res. ;149(2):236-242.
3.
Figure 4

Figure 4. Immunoglobulin A (IgA) and polymeric immunoglobulin receptor (pIgR) in the lung. From: Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels.

Parenteral nutrition (PN) fed mice had significantly decreased lung homogenate IgA (c) levels compared to Chow. There was no significant difference in bronchoalveolar lavage IgA (a) levels between Chow and PN fed mice. Lung homogenate pIgR levels were increased in PN animals. Two bands ∼120 (pIgR) and ∼94 (secretory component) kDa were detected by Western blot (b). Values are expressed as mean ± SE. *p<0.05 vs. Chow

Yoshifumi Sano, et al. J Surg Res. ;149(2):236-242.
4.
Figure 1

Figure 1. Secretory Immunoglobulin A (IgA) production through the mucosal immune system. From: Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels.

Luminal antigen taken up by M cells sensitized naïve T and B lymphocytes attracted into the Peyer's patches (PP) by mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) The lymphocytes migrate through mesenteric lymph nodes (MLN), the thoracic duct and into the blood stream. Mature lymphocytes home to the lamina propria (LPL) of effector site organs to produce IgA. IgA produced by plasma cell is transported to the mucosal surfaces by polymeric immunoglobulin receptor (pIgR) and secreted as a secretory IgA, which binds to bacteria to prevent invasive infection.

Yoshifumi Sano, et al. J Surg Res. ;149(2):236-242.

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