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Results: 4

2.
FIG. 4.

FIG. 4. From: Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas.

T2-weighted MRI images of the frontal injection site areas in a control macaque (A) and a high-dose macaque (B). There is no evidence of encephalitis or other abnormality in either animal.

Rae Myers, et al. Hum Gene Ther. 2008 July;19(7):690-698.
3.
FIG. 3.

FIG. 3. From: Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas.

Vero cell overlay of CSF obtained on day 9 from a macaque treated with a high dose of virus. (A) Overlay of CSF supernatant; (B) overlay of cell pellet; (C and D) positive controls; (E) negative control.

Rae Myers, et al. Hum Gene Ther. 2008 July;19(7):690-698.
4.
FIG. 2.

FIG. 2. From: Toxicology Study of Repeat Intracerebral Administration of a Measles Virus Derivative Producing Carcinoembryonic Antigen in Rhesus Macaques in Support of a Phase I/II Clinical Trial for Patients with Recurrent Gliomas.

Schematic representation of MV-CEA. The cDNA encoding the human CEA was inserted upstream of the nucleocapsid (N) gene. P, phosphoprotein gene; M, matrix protein gene; F, fusion protein gene; H, hemagglutinin gene; L, large protein gene. Adapted with permission from Peng, K.W., Facteau, S., Wegman, T., O'Kane, D., and Russell, S.J. (2002b). Non-invasive in vivo monitoring of trackable viruses expressing soluble marker peptides. Nat. Med. 8, 527–531.

Rae Myers, et al. Hum Gene Ther. 2008 July;19(7):690-698.

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