Figure 1

Figure 1. Two Possible Modes of Polymerase Binding to DNA: Preassembly versus Neoassembly. From: The Dynamic Range of Transcription.

Two models for polymerase transcriptional recruitment to genes. In the upper half, the polymerase subunits are recruited to the promoter where they assemble there into a functional enzyme. In the lower half, the polymerases are preassembled and recruited as whole units helped by the interaction with transcription factors. While these two models seem very similar, the upper one offers more opportunity for regulation since the stoichiometry of the subunits can influence the initiation process.

Xavier Darzacq, et al. Mol Cell. ;30(5):545-546.

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