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Results: 4

1.
Figure 1

Figure 1. From: BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF DIFFERENT RECOMBINANT ACID ?-GLUCOSIDASE PREPARATIONS EVALUATED FOR THE TREATMENT OF POMPE DISEASE.

IEF and oligosaccharide profiling analyses of recombinant acid α-glucosidase preparations. (a) IEF analysis of CHO-GAA (lane 2), HP-GAA (lane 3) and tgGAA (lane 4). Isoelectric point markers are shown in lane 1. (b) Oligosaccharide profiles of CHO-GAA, HP-GAA and tgGAA. Regions of the chromatogram containing neutral, sialylated (NANA), mannose-6-phosphate-containing (M6P) and bis mannose-6-phosphate-containing (Bis M6P) glycans are noted.

A.J. McVie-Wylie, et al. Mol Genet Metab. ;94(4):448-455.
2.
Figure 3

Figure 3. From: BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF DIFFERENT RECOMBINANT ACID ?-GLUCOSIDASE PREPARATIONS EVALUATED FOR THE TREATMENT OF POMPE DISEASE.

Metamorph glycogen analysis of heart and quadriceps tissue from GAA knockout mice administered CHO-GAA, tgGAA and HP-GAA for 4 weekly doses of 20, 60 and 100 mg/kg (mean ± SD). * indicates p<0.05 as compared to vehicle.

A.J. McVie-Wylie, et al. Mol Genet Metab. ;94(4):448-455.
3.
Figure 4

Figure 4. From: BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF DIFFERENT RECOMBINANT ACID ?-GLUCOSIDASE PREPARATIONS EVALUATED FOR THE TREATMENT OF POMPE DISEASE.

Enzyme activity analysis of heart and quadriceps from GAA knockout mice administered CHO-GAA, tgGAA and HP-GAA for 4 weekly doses of 20, 60 and 100 mg/kg (mean ± SD). * indicates p<0.05 as compared to tgGAA and CHO-GAA; # indicates p<0.05 as compared to tgGAA and HP-GAA.

A.J. McVie-Wylie, et al. Mol Genet Metab. ;94(4):448-455.
4.
Figure 2

Figure 2. From: BIOCHEMICAL AND PHARMACOLOGICAL CHARACTERIZATION OF DIFFERENT RECOMBINANT ACID ?-GLUCOSIDASE PREPARATIONS EVALUATED FOR THE TREATMENT OF POMPE DISEASE.

Receptor binding and fibroblast cell uptake analyses of CHO-GAA, HP-GAA and tgGAA. (a and b) The relative binding affinities of CHO-GAA, HP-GAA and tgGAA for the mannose-6-phosphate receptor (panel a) and the mannose receptor (panel b) were evaluated by surface plasmon resonance (BIAcore). (c) Cellular uptake of these recombinant acid α-glucosidase preparations was determined using human Pompe fibroblasts.

A.J. McVie-Wylie, et al. Mol Genet Metab. ;94(4):448-455.

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