Results: 4

1.
Figure 3

Figure 3. From: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.

Plot of expression level of three candidate target genes in six of the MPNSTs, normalized with the average expression of three endogenous controls (B2M, GAPDH and TBP). The expression level was determined relative to the average expression of two benign tumors. No detection of PCR-product is indicated with an asterisk (*).

Stine H Kresse, et al. Mol Cancer. 2008;7:48-48.
2.
Figure 1

Figure 1. From: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.

Heat map of DNA copy number ratios of seven MPNSTs relative to a pool of normal diploid DNA. A total of 3,167 unique genomic clones are shown in chromosomal order from 1ptel to 22qtel. Chromosomes are indicated with black and grey bars. Red, increases in DNA copy number; green, decreases in DNA copy number.

Stine H Kresse, et al. Mol Cancer. 2008;7:48-48.
3.
Figure 2

Figure 2. From: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.

(A) Genome-wide frequency plot of copy number alterations identified by ACE in seven MPNSTs. Red, increases in DNA copy number; green, decreases in DNA copy number. (B) Representative whole genome DNA copy number profile for MPNSTs. Log2 ratio for each of the genomic clones is plotted according to chromosome position.

Stine H Kresse, et al. Mol Cancer. 2008;7:48-48.
4.
Figure 4

Figure 4. From: DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.

(A) DNA copy number profile of chromosome 17 for seven MPNSTs. Log2 ratio for each of the genomic clones is plotted according to chromosome position using "moving average smoothing" with a three-clone window. The minimal recurrent region (MRR) gained in all five patients with poor outcome is indicated, as well as the region where at least four of the five patients showed gain (highlighted by a square). (B) Plot of expression level of four candidate target genes in 17q in six of the MPNSTs, normalized with the average expression of three endogenous controls (B2M, GAPDH and TBP). The expression level was determined relative to the average expression of two benign tumors. (C) Plot of expression level of five candidate target miRNAs in 17q in six of the MPNSTs, normalized with the average expression of two endogenous controls (RNU6B and -24). The expression level was determined relative to the average expression of two benign tumors.

Stine H Kresse, et al. Mol Cancer. 2008;7:48-48.

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