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Results: 3

1.
Figure 2

Figure 2. From: Effects of Aging on Cerebral Blood Flow, Oxygen Metabolism, and Blood Oxygenation Level Dependent Responses to Visual Stimulation.

Covariance of calculated and measured parameters. (A) Fractional changes in CBF as a function of CMRO2 showing a similar slope, n, for both younger and older subjects. (B) Comparison of n with baseline CBF, showing no significant correlation. Younger subjects did have a significantly higher mean baseline CBF than older subjects. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

Beau M. Ances, et al. Hum Brain Mapp. ;30(4):1120-1132.
2.
Figure 3

Figure 3. From: Effects of Aging on Cerebral Blood Flow, Oxygen Metabolism, and Blood Oxygenation Level Dependent Responses to Visual Stimulation.

Single block averaged dynamics of the BOLD and CBF responses for older and younger subjects. A signal averaged block of 80 s (20 s of rest, 20 s of stimulus, and 40 s of rest) was assessed for both older and younger subjects. (A) The magnitude of the CBF response was similar for both groups. (B) A significant decrease in the magnitude of the BOLD response was seen in older compared to younger subjects. (C) In contrast, the undershoot period for the CBF response was significantly different. (D) However, a similar BOLD poststimulus undershoot was seen for both groups. For panels (A) and (B) the solid black bars indicate stimulus presentation. For each figure the standard errors are shown and are presented at every other time point sampled for time series data. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

Beau M. Ances, et al. Hum Brain Mapp. ;30(4):1120-1132.
3.
Figure 1

Figure 1. From: Effects of Aging on Cerebral Blood Flow, Oxygen Metabolism, and Blood Oxygenation Level Dependent Responses to Visual Stimulation.

Functional changes in the blood oxygen level dependent (BOLD) and cerebral blood flow (CBF) response in the VC for mild hypercapnia and functional activation. The panels show average response curves and standard errors for the CBF activated voxels within healthy younger (n = 10) and older (n = 10) subjects. (A) Fractional changes in the CBF responses to hypercapnia, (B) Changes in the BOLD responses to hypercapnia, (C) Fractional changes in the CBF responses to activation, and (D) Changes in the BOLD responses to activation. A significant increase in the fractional changes in the CBF response to hypercapnia was seen in older subjects compared to younger subjects leading to a decrease in the M value for older subjects. For the functional activation task the BOLD response was greater for younger compared to older subjects. For all panels the solid bars indicate stimulus presentation. For all time series data the error bars are presented at every other time point that was sampled. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]

Beau M. Ances, et al. Hum Brain Mapp. ;30(4):1120-1132.

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