Results: 5

1.
Figure 1

Figure 1. From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ?4 allele.

Age of onset is significantly affected by lhcgr2 genotype in males. AoO in lhcgr2 heterozygous and homozygous males (n = 50, p = 0.001).

Ryan J Haasl, et al. BMC Med Genet. 2008;9:37-37.
2.
Figure 2

Figure 2. From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ?4 allele.

Risk associated with ε4 allele is negated in male, lhcgr2 heterozygotes. Contingency table illustrating the relative frequencies of lhcgr2/APOE genotypes in males and females (black = AD; white = Control).

Ryan J Haasl, et al. BMC Med Genet. 2008;9:37-37.
3.
Figure 3

Figure 3. From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ?4 allele.

Novel missense mutation in exon 11 of LHCGR. (A) Chromatogram from one of two samples heterozygous for a novel C->T (Arg->Stop) missense mutation in codon 479 (exon 11) of LHCGR. (B) Chromatogram from a sample homozygous for 'C' at the same site.

Ryan J Haasl, et al. BMC Med Genet. 2008;9:37-37.
4.
Figure 4

Figure 4. From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ?4 allele.

lhcgr2 shares similarity with consensus 3' acceptor splice sites and ApoE mRNA. (A) lhcgr2 as a potential miRNA that regulates the expression of ApoE. The reversed LHCGR sequence is complimentary to a fragment of APOE mRNA at 13 out of 16 sites. (B) Pairwise sequence alignment of a portion of LHR intron 1 in human and mouse (Mus musculus). The human sequence includes lhr2 (rs4073366) and bears sequence features characteristic of 3' acceptor splice sites.

Ryan J Haasl, et al. BMC Med Genet. 2008;9:37-37.
5.
Figure 5

Figure 5. From: A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ?4 allele.

Significant linkage disequilibrium between lhcgr1 and multiple LHB loci. In the schematic of LHB, exons are represented as black boxes and the positions of the 7 LHB polymorphisms scored are indicated by vertical lines. lhb3 is composed of two SNPs, which are in complete LD with each other. For each polymorphism, genotype frequencies are represented in the form of two pie charts, where the left chart represents genotype frequencies among individuals lacking an LQ-insert allele in exon 1 of LHCGR (lhcgr1) and the right chart represents genotype frequencies among individuals possessing 1 or 2 LQ-insert alleles. Frequencies above the graphs correspond to AD males, while frequencies below the graph correspond to all individuals sampled in this study. * = significant difference (p < 0.05), ** = highly significant difference (p < 0.01).

Ryan J Haasl, et al. BMC Med Genet. 2008;9:37-37.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk