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Results: 4

1.
Figure 4

Figure 4. From: EFFECT OF NALTREXONE AND ONDANSETRON ON ALCOHOL CUE-INDUCED ACTIVATION OF THE VENTRAL STRIATUM IN ALCOHOL-DEPENDENT PEOPLE.

There is a strong curvolinear relationship across groups between the mean craving for alcohol during the scanning session and the mean of the alcohol minus beverage comparison (B=.04, Se=.0048, p= 002) in the ventral striatum.

Hugh Myrick, et al. Arch Gen Psychiatry. ;65(4):466-475.
2.
Figure 1

Figure 1. From: EFFECT OF NALTREXONE AND ONDANSETRON ON ALCOHOL CUE-INDUCED ACTIVATION OF THE VENTRAL STRIATUM IN ALCOHOL-DEPENDENT PEOPLE.

Subjective craving for alcohol and beverage cues were rated within the scanner. Subjects treated with the combination of naltrexone/ondansetron had significantly less craving for alcohol as compared to placebo-treated subjects (p=.035). In addition, social drinking controls had less craving for alcohol as compared to placebo-treated subjects (p=.001).

Hugh Myrick, et al. Arch Gen Psychiatry. ;65(4):466-475.
3.
Figure 2

Figure 2. From: EFFECT OF NALTREXONE AND ONDANSETRON ON ALCOHOL CUE-INDUCED ACTIVATION OF THE VENTRAL STRIATUM IN ALCOHOL-DEPENDENT PEOPLE.

Brain regions with significantly increased activation in one task (alcohol) compared with another (beverage) are depicted in color on coronal structural magnetic resonance imaging scans (p ≤.001).

Hugh Myrick, et al. Arch Gen Psychiatry. ;65(4):466-475.
4.
Figure 3

Figure 3. From: EFFECT OF NALTREXONE AND ONDANSETRON ON ALCOHOL CUE-INDUCED ACTIVATION OF THE VENTRAL STRIATUM IN ALCOHOL-DEPENDENT PEOPLE.

Ventral striatum activation (contrast of alcohol-cue activation minus beverage-cue activation) was significantly decreased in the combination naltrexone/ondansetron group (p=.02), the naltrexone alone (p=.049), and the social drinking controls (p=.001) as compared to placebo treated subjects.

Hugh Myrick, et al. Arch Gen Psychiatry. ;65(4):466-475.

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