Results: 3

1.
Figure 3

Figure 3. Comparative analysis between different treatment regimens.. From: Pharmacogenomics of Interferon-ß Therapy in Multiple Sclerosis: Baseline IFN Signature Determines Pharmacological Differences between Patients.

Comparison of biological response of Avonex treated patients and Betaferon or Rebif treated patients. A. Average biological response using the set of 15 IFN-induced genes in the test group of 16 RRMS patients; B. Biological response using PCR based gene expression levels for RSAD2 in the second independent validation group of 30 RRMS patients.

Lisa G. M. van Baarsen, et al. PLoS ONE. 2008;3(4):e1927.
2.
Figure 2

Figure 2. Correlation between baseline and biological response to IFNß therapy.. From: Pharmacogenomics of Interferon-ß Therapy in Multiple Sclerosis: Baseline IFN Signature Determines Pharmacological Differences between Patients.

Biological responses were calculated, using a set of IFN-induced genes (A and B) or a single IFN-induced gene (C and D) and correlated with baseline levels, resulting in a significant negative correlation. In C and D the expression levels of RSAD2 is measured by quantitative realtime PCR and normalized to the expression levels of GAPDH. A. IFN cluster as described in ; B. Selection of 15 genes; C. Biological response after three months, using RSAD2 gene expression levels; D Biological response after six months using RSAD2 gene expression levels.

Lisa G. M. van Baarsen, et al. PLoS ONE. 2008;3(4):e1927.
3.
Figure 1

Figure 1. A. Biological response to IFNß therapy in MS patients. From: Pharmacogenomics of Interferon-ß Therapy in Multiple Sclerosis: Baseline IFN Signature Determines Pharmacological Differences between Patients.

Two-way hierarchical cluster analyses using gene expression ratio's (biological response). This diagram contains genes that were at least two-fold up- or downregulated after IFNß therapy in at least seven patients. Upregulated genes after therapy are indicated by a red colour, downregulated by a green colour and genes that show no differences in expression after therapy are indicated in black. B. Cluster of IFN-induced genes Selection of genes clustering together based on similar biological response profiles within the patient group. The genes clustered together with a correlation of 0.925 and are known to be induced by IFN. The mean expression ratio of all genes in this IFN cluster is referred to as the biological IFN response.

Lisa G. M. van Baarsen, et al. PLoS ONE. 2008;3(4):e1927.

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