Results: 5

1.
Figure 4

Figure 4. From: IMPROVED TRANSFORMATION OF MORPHOMETRIC MEASUREMENTS FOR A PRIORI PARAMETER ESTIMATION IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL OF ETHANOL.

Optimization Block Diagram. The computations required for the optimization loop are illustrated.

Martin H. Plawecki, et al. Biomed Signal Process Control. ;2(2):97-110.
2.
Figure 5

Figure 5. From: IMPROVED TRANSFORMATION OF MORPHOMETRIC MEASUREMENTS FOR A PRIORI PARAMETER ESTIMATION IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL OF ETHANOL.

Original Experiment. The subject BrAC response control algorithm, as implemented within the laboratory, is illustrated.

Martin H. Plawecki, et al. Biomed Signal Process Control. ;2(2):97-110.
3.
Figure 1

Figure 1. From: IMPROVED TRANSFORMATION OF MORPHOMETRIC MEASUREMENTS FOR A PRIORI PARAMETER ESTIMATION IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL OF ETHANOL.

Graphical Depiction of an Ideal Alcohol Clamp, denoted by CRef (t). For the experimental records described here, the clamp consisted of a linear rise in concentration to 60mg% in 15 minutes, 180 minutes at 60mg%, and then an uncontrolled, but monitored descent. Major experimental regions are identified.

Martin H. Plawecki, et al. Biomed Signal Process Control. ;2(2):97-110.
4.
Figure 3

Figure 3. From: IMPROVED TRANSFORMATION OF MORPHOMETRIC MEASUREMENTS FOR A PRIORI PARAMETER ESTIMATION IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL OF ETHANOL.

Infusion Profile and BrAC Reconstruction. A typical clamp infusion profile and its resultant BrAC and reconsultant are depicted. As noted within Appendix I, the infusion rate is provided in terms of dL of infusate per hour where the infusate is a 6% by volume mixture of alcohol in Ringer’s lactate.

Martin H. Plawecki, et al. Biomed Signal Process Control. ;2(2):97-110.
5.
Figure 2

Figure 2. From: IMPROVED TRANSFORMATION OF MORPHOMETRIC MEASUREMENTS FOR A PRIORI PARAMETER ESTIMATION IN A PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL OF ETHANOL.

Estimation Procedure for the Alcohol Infusion Profile. To begin, a desired Reference BrAC response, CRef (t), is identified; an alcohol clamp for the context of this paper. Next, the model response to an initially zero infusion profile, MInfused (t), is calculated, yielding Model BrAC response CModel (t,Ω). This is compared to the reference response, creating an error signal, e (t), which drives the computer adjust k (.). This process adjusts the next value of the estimated infusion profile. This process is repeated for each step of the simulation interval, pre-computing the infusion profile.

Martin H. Plawecki, et al. Biomed Signal Process Control. ;2(2):97-110.

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