Results: 3

1.
Fig. 2.

Fig. 2. From: Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

Infant distress vocalization as a function of the OPRM1 C77G genotype (C/C, ■, or C/G, ▴). Values are mean frequencies of vocalizations (± SEM) during the chronic phase of four consecutive (S1–S4) cycles of mother–infant separation. 77G carriers showed overall higher vocalization [main effect of genotype: n = 25 vs. 64; F(1,88) = 5.2, P = 0.025], and had a differential temporal course of the response over successive separations [genotype × time interaction, F(3,246) = 4.2, P = 0.007]. The OPRM1 C77G genotype and its interaction with separation exposure accounted for 9.4% of the observed variance in vocalization.

Christina S. Barr, et al. Proc Natl Acad Sci U S A. 2008 April 1;105(13):5277-5281.
2.
Fig. 1.

Fig. 1. From: Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

Infant attachment as a function of the OPRM1 C77G genotype. Attachment was measured as factor scores (mean ± SEM) extracted from a range of behaviors scored during a critical developmental phase (18–24 months of age) as described in Table 1. Scores were significantly higher in 77G allele carriers [n = 27 vs. 69; F(1,94) = 5.6, P = 0.017]. The proportion of variance in attachment behavior accounted for by the OPRM1 C77G genotype, measured as partial eta2, was 5.7%.

Christina S. Barr, et al. Proc Natl Acad Sci U S A. 2008 April 1;105(13):5277-5281.
3.
Fig. 3.

Fig. 3. From: Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates.

Social preference mother-infant reunion as a function of the OPRM1 C77G genotype (C/C, ■, or C/G, ▴). Values are given as the average duration of time that an infant spent in social contact with its mother or with other members of the social group (sec ± SEM) in a 300-sec scoring session during each of four reunion cycles (R1–R4). (A) Social Contact-Mother: 77G allele carriers had a different course of behavior over separation cycles than did 77C homozygotes [n = 26 vs. 64; OPRM1 genotype x time interaction, F(3,252) = 3.2, P = 0.02]. The interaction of OPRM1 genotype with time accounted for 5.6% of the variance in this behavior. (B) Social Contact-Other: Among carriers of the G allele, there was a decrease in the amount of time spent with other group members over repeated separation–reunion cycles [F(3,243) = 3, P = 0.03].

Christina S. Barr, et al. Proc Natl Acad Sci U S A. 2008 April 1;105(13):5277-5281.

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