Results: 4

1.
Fig. 3

Fig. 3. From: Relationship between mRNA expression of splice forms of the ?1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

mRNA densities of ζ1-pan and ζ1-1. Graphs showing densities of mRNA expression of ζ1-pan (A) and ζ1-1 splice form (B) in prefrontal cortical regions of mice brain. * p< 0.05 for difference in expression of mRNA from 4-months old animals. Data indicate mean±SE. Lat orb, lateral orbital cortex; vent orb, ventral orbital cortex; sup, superficial cortical layers II–III; deep, cortical layers IV–VI.

Siba R. Das, et al. Brain Res. ;1207:142-154.
2.
Fig. 1

Fig. 1. From: Relationship between mRNA expression of splice forms of the ?1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

Performance of mice in behavioral trials. Figures above show performance in 12 days of place trials (A), 6 days of probe trials (on even place trial days; B) and learning index scores from probe trial data (C) for the reference memory tasks; averaged naïve (T0) and delayed (Tdelay) trials (D) and the ratio, T0/Tdelay (E) for working memory tasks and cued control trials at the 6 different platform positions (F) for the 4, 11 and 26-month old mice. * p< 0.05 for differences from 4-month old animals for the same trials, # p< 0.05 for differences from 11-month old animals for the same trial(s), † p< 0.05 for differences from overall performance in naïve trials (T0) within same age group. (A, B, D & E) Significant differences were seen with the averages across all trials.

Siba R. Das, et al. Brain Res. ;1207:142-154.
3.
Fig. 4

Fig. 4. From: Relationship between mRNA expression of splice forms of the ?1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

Graphs showing correlation analysis of mRNA for the ζ1-a splice form in orbital cortices of old mice and performance in a reference memory task, as shown by learning index scores (A); in a working memory task, as shown by the ratio of T0/Tdelay (B); and in the cued control task, as shown by averaged cumulative proximity (cum prox; C). D) Graph showing correlation analysis between performance in the working memory task and cued trials. Please note that high learning index scores and cumulative proximities are associated with poor performance in reference and cued trials, respectively. High T0/Tdelay ratios indicate good performance. Lat orb, lateral orbital cortex; vent orb, ventral orbital cortex; T0, initial naïve trial; Tdelay, first test trial with 10 minute delay from naïve trial; corr p, corrected p-value (p_ACT statistical method).

Siba R. Das, et al. Brain Res. ;1207:142-154.
4.
Fig. 2

Fig. 2. From: Relationship between mRNA expression of splice forms of the ?1 subunit of the N-methyl-D-aspartate receptor and spatial memory in aged mice.

Representative film images of mRNA hybridization of different splice forms of behaviorally characterized animals. In situ hybridization images from a young mouse for ζ1-pan (A) and ζ1-1 (B). ζ1-3 mRNA showed higher density of hybridization in some areas in young behaviorally-characterized animal brain (C) than in the old animals from the same behavioral group (D). ζ1-a mRNA showed lower densities of hybridization in many regions of young animal brains (E) than in the old animals (F). Representative in situ image from a young mouse for ζ1-b (G). Diagrams adapted from Paxinos and Franklin (2001) showing analyzed brain regions of the prefrontal and frontal cortex of mice used in this study (H & I). Even numbers indicate superficial layers (II and III) and odd numbers indicate deep layers (IV–VI) of prefrontal and frontal cortical regions of mouse brain. 1, 2 ventral orbital cortex; 3, 4 lateral orbital cortex; 5, 6 medial prefrontal cortex; 7, 8 secondary motor cortex; 9, 10 primary motor cortex; 11, 12 somatosensory cortex and 13, 14 insular cortex. Standard images and the equivalent pmol of labeled 33P/mm2 tissue are shown to the right of each brain image.

Siba R. Das, et al. Brain Res. ;1207:142-154.

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