Results: 2

1.
Fig. 1.

Fig. 1. From: Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.

General schematic of model reflecting uninfected CD4+ T lymphoblasts (TU), early-stage-infected CD4+ T lymphoblasts (T1), late-stage-infected CD4+ T lymphoblasts (T2), uninfected M cells (MU), early-stage-infected M cells (M1), and late-stage-infected M cells (M2). The death rates of these cell are represented by δTU, δT1, δT2, δMU, δM1, and δM2, respectively. kT and kM define the rates at which T1 transition to T2 and M1 transition to M2, respectively. Free virus (V) is cleared at a rate c and produced by T2 with a burst size of NT and by M2 with burst size NM. λT and λM represent CD4+ T lymphoblast and M cell production. βT and βM reflect virus infectivity with respect to CD4+ T lymphoblasts and M cells.

Ahmad R. Sedaghat, et al. Proc Natl Acad Sci U S A. 2008 March 25;105(12):4832-4837.
2.
Fig. 2.

Fig. 2. From: Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.

The decay of virus production upon initiation of HAART in the presence of an integrase inhibitor (red; kT = kM = 0) or RT inhibitor (blue; βT = βM = 0) from late-stage-infected CD4+ T lymphoblasts (A), late-stage-infected M cells (B), and both late-stage-infected CD4+ T lymphoblasts and late-stage-infected M cells (C). Unless otherwise noted, parameters used kT = 0.1 day−1, kM = 0.1 day−1, δTU = 0.02 day−1, δT1 = 0.50 day−1, δT2 = 1.00 day−1, δMU = 0.0495 day−1, δM1 = 0.0495 day−1, δM2 = 0.0495 day−1, λT = 2 × 109 cells per day, λM = 4.95 × 108 cells per day, c = 23 day−1, NT = 1,000 virions per cell per day, NM = 100 virions per cell per day, βT = 8 × 10−12 virions−1·day−1, βM = 8 × 10−15 virions−1·day−1.

Ahmad R. Sedaghat, et al. Proc Natl Acad Sci U S A. 2008 March 25;105(12):4832-4837.

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