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2.
Figure 2

Figure 2. From: Bcl-2-family proteins and hematologic malignancies: history and future prospects.

Functional interactions among the types of mammalian Bcl-2–family proteins at mitochondrial membranes.

John C. Reed. Blood. 2008 April 1;111(7):3322-3330.
3.
Figure 1

Figure 1. From: Bcl-2-family proteins and hematologic malignancies: history and future prospects.

Bcl-2 suppresses apoptosis, necrosis, and autophagy. ROS indicates reactive oxygen species; Cyt-c, cytochrome-c; EndoG, endonuclease G; AIF, apoptosis-inducing factor; and IAP, inhibitor of apoptosis protein.

John C. Reed. Blood. 2008 April 1;111(7):3322-3330.
4.
Figure 3

Figure 3. From: Bcl-2-family proteins and hematologic malignancies: history and future prospects.

Nonfamilial interactions with antiapoptotic proteins Bcl-2 or Bcl-XL and with proapoptotic proteins Bax or Bak. (A) The depicted protein interactions have been reported for either Bcl-2 or Bcl-XL. (B) The depicted protein interactions have been reported for Bax or Bak. In many cells, Bax is present in a latent (inactive) conformation in the cytosol,57 in which its C-terminal transmembrane domain is folded onto the protein.64 Activators of Bax induce conformational changes that promote Bax's insertion into membranes of mitochondria, followed by BH3-induced oligomerization in membranes. Several proteins that modulate these steps have been reported.

John C. Reed. Blood. 2008 April 1;111(7):3322-3330.

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