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1.
Figure 6

Figure 6. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

Matched histological sample of papillary carcinoma solid variant. At higher magnification note the nuclear features of the neoplastic cells leading to the morphological diagnosis of PTC in its solid variant. (H&E staining 25×)

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.
2.
Figure 5

Figure 5. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

Matched histological sample of papillary carcinoma solid variant. Note the solid architecture of this carcinoma traversed by delicate fibrous septa that delimitates islands and sheets of neoplastic cells (H&E staining 10×)

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.
3.
Figure 1

Figure 1. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

FNC sample of a solid variant of PTC. At low power, in a clean background solid aggregates of epithelial follicular cells arranged in syncytial-type tissue fragments are observed (Diff-Quick® staining 4×)

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.
4.
Figure 2

Figure 2. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

FNC sample of a solid variant of PTC. Microscopic field containing monolayered epithelial cellular sheets. Note the occurrence of nuclar overlapping and crowding and also of a certain degree of variability in cellular shape and size with anisocytosis and anisonucleosis. (Diff-Quick® staining 10×)

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.
5.
Figure 3

Figure 3. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

FNC sample of a solid variant of PTC. At higher magnification note the presence of enlarged nuclei with fine chromatin, with occasional nuclear grooves and micronucleoli. These changes prompted the performance of a second pass to perform BRAF molecular analysis. (Diff-Quick® staining 40×)

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.
6.
Figure 4

Figure 4. From: Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report.

Molecular analysis of BRAF mutational status on matched cyto-histological samples. Electrophoresys of the PCR product of BRAF exon (A). Sequencing profile/fluorograph of the matched cytological (B) and histological (C) samples with the respective nucleotide (Nt) sequences of WT (1 BRAFWT) and mutated (2 BRAFVK600-1E) alleles. The box red in wild-type sequence shows the deleted nucleotide triplet TGA 1799 – 1801.

Giancarlo Troncone, et al. Cytojournal. 2008;5:2-2.

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