Results: 2

1.
Figure 2

Figure 2. From: Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti-inflammatory activity in murine disease models.

Topical application of Tuhuai extract reduces the inflammatory response in both TPA and oxazolone models: ear inflammation was induced by topical TPA or oxazolone treatment. Skin samples were obtained 20 h after treatment. Significant reductions in inflammatory cell infiltration and ear thickness were seen in Tuhuai-treated ear. a and b are normal ear treated with Vehicle. c (TPA) and d (oxazolone) are inflammatory ear treated with Vehicle. e and f are inflammatory ear treated with Tuhuai. Scale bar = 100 μm. The ear thickness was measured with a digital caliper as described in Methods. Fig 2g is TPA model (P < 0.001 between all groups) and Fig 2h is oxazolone model (P < 0.01 between all groups). Data are expressed as mean + SEM. Numbers for each group are indicated in the figure.

Mao-Qiang Man, et al. Exp Dermatol. ;17(8):681-687.
2.
Figure 1

Figure 1. From: Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti-inflammatory activity in murine disease models.

Topical application of Tuhuai extract inhibits epidermal proliferation in an epidermal hyperproliferative model: an epidermal hyperproliferative model was established by repeated barrier disruption. Either Vehicle or 1% Tuhuai extract was applied topically following each barrier disruption. Figure 1a, c, e are H&E staining and b, d, f are anti-PCNA staining. Figure 1a, b are normal skin. Figure 1c, d are hyperproliferative skin treated with Vehicle. And figure 1e, f are hyperproliferative skin treated with Tuhuai extract. The magnifications for all are the same. Scale bar = 20 μm. Epidermal thickness of nucleated cell layer was measured on 100X H&E sections at every 2 cm points along the epidermis (Figure 1g, n = 10 for normal; n = 30 for Vehicle treated and n = 34 for Tuhuai treated). Number of PCNA positive cells was counted on every 1 cm segment along epidermis (Figure 1h, n = 60 for normal; n = 63 for Vehicle treated, and n = 67 for Tuhuai treated). The data are expressed as mean of all measured points. The significances are shown on the figure. And *P < 0.001 is for the difference between normal and Tuhuai treated.

Mao-Qiang Man, et al. Exp Dermatol. ;17(8):681-687.

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