Results: 4

1.
FIG. 4.

FIG. 4. From: Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors .

Passive protection of complement-deficient and FcR-deficient mice. A/J mice, CVF-treated C57BL/6 mice, and CVF-treated FcR−/− mice were given mouse anti-Ba serum (▵) or normal mouse serum (○) and challenged with 2 × 106 to 4 × 106 spores of strain 7702 delivered by aerosol. The survival of each group is shown. For each strain, the cumulative mortality of three independent challenges is represented in the graph (n = 18 for each A/J group, n = 13 for each BL/6 group, and n = 22 for each FcR−/− group).

Eric T. Harvill, et al. Infect Immun. 2008 May;76(5):2177-2182.
2.
FIG. 3.

FIG. 3. From: Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors .

Passive protection of convalescent-immunodeficient mice with anti-B. anthracis sera. μMT and TCRα−/− mice were exposed to aerosols of spores prepared from B. anthracis strain 7702 as described in Materials and Methods. At 4 weeks after primary challenge, all mice were challenged with 109 spores of strain 7702 delivered i.p. Immediately prior to rechallenge, half of each group of convalescent mice received mouse anti-Ba serum (▵) and the other half received normal mouse serum (○). The survival of each group is shown (n = 9).

Eric T. Harvill, et al. Infect Immun. 2008 May;76(5):2177-2182.
3.
FIG. 2.

FIG. 2. From: Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors .

Serum IgG levels in T-cell-deficient mice. C57BL/6 and TCRα−/− mice were exposed to aerosols of spores prepared from B. anthracis strain 7702 as described in the text. Prior to exposure and 2, 4, and 6 weeks after exposure, mice were bled and serum titers against PA (anti-PA) (A) and heat-killed B. anthracis cells (anti-HKBa) (B) were determined as described in Materials and Methods. Statistical significance was determined by using Student t test analysis. In all cases, means were compared to those of the naive control group (*, P < 0.05; **, P < 0.005; ***, P < 0.0005).

Eric T. Harvill, et al. Infect Immun. 2008 May;76(5):2177-2182.
4.
FIG. 1.

FIG. 1. From: Anamnestic Protective Immunity to Bacillus anthracis Is Antibody Mediated but Independent of Complement and Fc Receptors .

Primary (A) and secondary (B) challenge of immunodeficient mice. Naive mice were exposed to aerosols of spores prepared from B. anthracis strain 7702 as described in the text. Survival of groups of mice with retained doses between 2 × 106 and 4 × 106 spores after aerosol challenge is shown. For each strain, the cumulative mortality of three independent challenges is represented in the graph (n = 30). Convalescent mice that survived the primary challenges were subsequently challenged with 109 spores of strain 7702 injected by the i.p. route 4 weeks after the original exposure. In each experiment, a group of naive C57BL/6 mice was included as a positive control for the challenge. The survival of each group is shown. For each mouse strain, the cumulative mortality of three independent challenges is represented in the graph (n = 30), except for the μMT group, for which one mouse died in the primary challenge (n = 29).

Eric T. Harvill, et al. Infect Immun. 2008 May;76(5):2177-2182.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk