Display Settings:

Items per page
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 13

1.
Figure 13

Figure 13. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Mechanistic proposal for the oxidation of FMN 79 to dimethylbenzimidazole 87.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
2.
Figure 8

Figure 8. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

MoaA and MoaC catalyze the formation of Precursor Z (49) on the molybdopterin biosynthetic pathway.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
3.
Figure 12

Figure 12. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Mechanistic proposal for the oxidative decarboxylation of coproporphyrinogen III (74) to protoporphyrinogen IX (75).

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
4.
Figure 11

Figure 11. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Shown is the mechanistic proposal for the formation of quinolinic acid 68 from hydroxyanthranilate (69).

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
5.
Figure 7

Figure 7. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

A new thiamin salvage pathway for the recycling of the pyrimidine of thiazole-degraded thiamin.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
6.
Figure 10

Figure 10. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Shown is the major bacterial pathway for the formation of the quinolinic acid (68) precursor to NAD 28.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
7.
Figure 3

Figure 3. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Mechanistic proposal for the ThiH-catalyzed formation of glycine imine (14) under anaerobic conditions.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
8.
Figure 5

Figure 5. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Mechanistic proposal for the formation of the thiamin thiazole (41) in S. cerevisiae.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
9.
Figure 4

Figure 4. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Labeling studies that map out the complex conversion of aminoimidazole ribotide to the thiamin pyrimidine.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
10.
Figure 9

Figure 9. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

A mechanistic proposal for the formation of PLP (43). Pdx1 represents the pyridoxal phosphate synthase.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
11.
Figure 1

Figure 1. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Thiamin phosphate 3 is biosynthesized by coupling the thiazole 1 with the pyrimidine 2.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
12.
Figure 2

Figure 2. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

Mechanistic proposal for the formation of the thiamin thiazole 1 in bacteria. ThiS represents the sulfide carrier protein.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.
13.
Figure 6

Figure 6. From: Cofactor biosynthesis - still yielding fascinating new biological chemistry.

The pyrimidine moiety of thiamin in S. cerevisiae is formed by a remarkable reaction sequence in which the histidine atoms labeled in blue and the PLP atoms labeled in red are incorporated into the pyrimidine 44.

Tadhg P. Begley, et al. Curr Opin Chem Biol. ;12(2):118-125.

Display Settings:

Items per page

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk