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1.
Figure 1

Figure 1. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

VEGF and ang-1 expression. a. Western blots. ang-1: CMVang-1, vegf: CMVVEGF, 1:1: CMVang-1 and CMVVEGF in a 1:1 ratio and HEPES: HEPES buffer. GAPDH was used as a loading control. b. Graph showing the quantification of VEGF and ang-1 expression (n=3). The expression of VEGF and ang-1 were normalized by the expression of GAPDH.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.
2.
Figure 4

Figure 4. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

Densities of capillaries and α-SMA positive vessels. (a) Capillary (CAP) numbers per cardiomyocyte (CMC) and (b) densities of α-SMA positive vessels per mm2 in hearts collected 4 weeks after vector injection. * indicates the differences between these groups and control groups (HEPES and CMVLacZ groups) are statistically significantly.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.
3.
Figure 2

Figure 2. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

LV FS% and infarct size. In this and the subsequent figures, hearts were injected with CMVVEGF alone (vegf), CMVang-1 alone (ang-1), CMVang-1 and CMVVEGF at 1:1, 1:2 and 1:2 ratios and with CMVLacZ (LacZ) and HEPES as controls. a. LV FS%. ** indicates the differences between these groups and the 2 control groups (LacZ and HEPES) were significant (p<0.05). b. Infarct size.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.
4.
Figure 5

Figure 5. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

Evans Blue dye leakage 4 weeks after LAD ligation and vector injection. Normal hearts from unoperated and uninjected mice were studied similarly as a control. * indicates that the differences between these groups and CMVVEGF (vegf) group are statistically significant.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.
5.
Figure 3

Figure 3. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

Regional wall motion 4 weeks post treatment. a. A sketch showing the LV divided into 5 regions for analysis. Infarct scar was located at region 3. The regions 2 and 4 embraced the junction of infarct and noninfarct myocardium. The regions 1 and 5 are noninfarct myocardium. Vectors were injected into region 4. b. Wall motion scores.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.
6.
Figure 6

Figure 6. From: Additive Effect of AAV Mediated Angiopoietin-1 and VEGF Expression on the Therapy of Infarcted Heart.

Proliferating cells. a. Graph showing the number of proliferating cells in the different groups quantified on sections stained by anti-Ki67 antibody. * indicates that the differences between these groups and the two control groups are statistically significant. b. Western blots show cyclin B1 expression. Proteins were extracted from hearts injected with CMVLacZ (lane 1), CMVang-1 (lane 2), CMVVEGF (lane 3), and CMVang-1 and CMVVEGF in a 1:1 ratio (lane 4). GAPDH was used as a loading control. c. Representative sections double-stained with antibodies specific for Ki67 (green and arrows) together with To-Pro3 (red) for nuclei (1), with antibody specific for SMA (red) to show proliferating vascular smooth muscle cells (2), with antibody specific for PECAM-1 (red) to show proliferating endothelial cells (3) or with Eriochrom blue-black R (red) to show proliferating cardiomyocytes (4). Scale bar=22 μm.

Hua Su, et al. Int J Cardiol. ;133(2):191-197.

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