Results: 3

1.
Figure 1

Figure 1. Normalized MBL2 levels corresponding to 6 MBL2 gene diplotypes (**00, XYA0, YYA0, XXAA, XYAA, and YYAA) in CF patient and parent cohorts. . From: Complex two-gene modulation of lung disease severity in children with cystic fibrosis.

(A and B) Distribution of normalized MBL2 expression values and median MBL2 expression values for each diplotype is shown for 600 parents (A) and 1,393 PI CF patients (B). (C and D) Comparison of normalized MBL2 expression values between patients and parents (C) and between 848 pediatric and 545 adult patients (D). Statistical difference was tested using the Wilcoxon rank-sum test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

Ruslan Dorfman, et al. J Clin Invest. 2008 March 3;118(3):1040-1049.
2.
Figure 2

Figure 2. Results of time-to-event analysis showing median age and 95% CI at first positive culture for P. aeruginosa. . From: Complex two-gene modulation of lung disease severity in children with cystic fibrosis.

The proportion of patients not infected with P. aeruginosa versus age is plotted for low MBL2 (**00 and XYA0; n = 136), intermediate MBL2 (YYA0 and XXAA; n = 311), and high MBL2 (YYAA and XYAA; n = 572) diplotype groups. The graph shows data for 1,019 pediatric (<18.5 years of age) PI CF patients. Median age of infection was 4.4 yr (95% CI, 3.2 to 6.4 yr) for the low MBL2 group, 7.0 yr (95% CI, 6.1 to 7.9 yr) for the intermediate MBL2 group, and 8.0 yr (95% CI, 7.2 to 8.8 yr) for the high MBL2 group. The survival probability differences were tested using log-rank test (P = 0.0003).

Ruslan Dorfman, et al. J Clin Invest. 2008 March 3;118(3):1040-1049.
3.
Figure 3

Figure 3. Results of time-to-event analysis (as in Figure 2) plotted for the 3 MBL2 diplotype groups and stratified by the codon 10 (rs1982073, L10P) TGFB1 genotypes. . From: Complex two-gene modulation of lung disease severity in children with cystic fibrosis.

Data are shown for 1,003 pediatric PI CF patients; no codon 10 results were available for 16 patients. (A) For the TT genotype (n = 389), median age at first positive P. aeruginosa culture was 5.7 yr (95% CI, 2.4 to 9.7 yr) for the low MBL2 group (n = 56), 7.1 yr (95% CI, 5.9 to 8.5 yr) for the intermediate MBL2 group (n = 115), and 7.4 yr (95% CI, 6.1 to 9.1 yr) for the high MBL2 group (n = 218). (B) For the CT genotype (n = 454), median age at first positive P. aeruginosa culture was 4.6 yr (95% CI, 3.5 to 9.7 yr) for the low MBL2 group (n = 53), 7.4 yr (95% CI, 5.9 to 8.9 yr) for the intermediate MBL2 group (n = 155), and 8.1 yr (95% CI, 7.1 to 9.4 yr) for the high MBL2 group (n = 246). (C) For the CC genotype (n = 160), median age at first positive P. aeruginosa culture was 3.1 yr (95% CI, 2.8 to 6.2 yr) for the low MBL2 group (n = 26), 6.7 yr (95% CI, 3.4 to 9.1 yr) for the intermediate MBL2 group (n = 34), and 8.7 yr (95% CI, 7.1 to 10.4 yr) for the high MBL2 group (n = 100). Differences between groups were determined by the log-rank test.

Ruslan Dorfman, et al. J Clin Invest. 2008 March 3;118(3):1040-1049.

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