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1.
Figure 1

Figure 1. From: Factors determining antibody distribution in tumors.

Poor penetration of trastuzumab (a) and doxorubicin (b) into tumor tissue in xenograft tumor samples. Capillaries are labeled red and the drugs are labeled green. Large zones are essentially free of drug. The scale bar represents 100 μm. Modified, with permission, from Refs. [4] and [6].

Greg M. Thurber, et al. Trends Pharmacol Sci. ;29(2):57.
2.
Figure 2

Figure 2. From: Factors determining antibody distribution in tumors.

Processes of antibody distribution in tumor tissue. (1) Extravasation of antibody across the tumor blood vessel walls is a function of the vessel permeability and occurs slowly. (2) Once in the tumor tissue, the antibodies diffuse freely in the extracellular matrix (a), with their motion retarded by formation of immobile complexes owing to binding (b) and dissociation (c), which are functions of affinity. (3) Antibody administered in the plasma, which supplies free antibody to the tumor, is cleared through several mechanisms, depending on its size, charge and Fc receptor binding. (4) While bound to surface antigens, local clearance of antibodies occurs owing to internalization and degradation at a rate determined by the target antigen.

Greg M. Thurber, et al. Trends Pharmacol Sci. ;29(2):57.

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