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Results: 5

1.
Figure 1

Figure 1. Neuroanatomical confirmation of successful injection into the lateral septum. From: Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

Only data from animals with confirmed bilateral injections were used in the statistical analysis of the behavioral experiments.

Andrey E. Ryabinin, et al. Neuroscience. ;151(3):780-790.
2.
Figure 2

Figure 2. Effects of a single dose of CRF or Ucn1 in the lateral septum on limited access ethanol consumption. From: Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

Left panel: Baseline intake of 20% v/v ethanol during a 2-hour session on Day 2 of Experiment 1 in three groups of animals after sham injections that were subsequently divided into treatment groups. No significant differences between groups are observed. Right panel: Intake of 20% ethanol during the 2-hour session on Day 3 of Experiment 1 following microinjections of vehicle (Veh), 40 pmol CRF or 40 pmol Ucn1. Both CRF and Ucn1 significantly suppressed ethanol consumption. The number of animals per group is shown in parenthesis.

Andrey E. Ryabinin, et al. Neuroscience. ;151(3):780-790.
3.
Figure 4

Figure 4. Dose response of Ucn1’s suppressive effects on limited access ethanol but not water consumption following intra-lateral septum microinjection. From: Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

Top left panel: Baseline intake of 20% v/v ethanol during a 2-hour session on Day 2 of Phase 1 of Experiment 3 following sham injections in four groups of animals that were subsequently divided into dose groups. No significant differences between groups are observed in baseline 2 hr ethanol intake. Top right panel: Intake of 20% ethanol during a 2-hour session on Day 3 of Phase 1 of Experiment 2 following injections of vehicle (Veh), 6, 20 or 60 pmol of Ucn1. All three doses of Ucn1 significantly attenuated ethanol intake. Bottom left panel: Intake of water during a 2-hour session on Day 2 of Phase 2 of Experiment 3 following sham injections in four groups of animals that were subsequently divided into dose groups. No significant differences are observed in baseline 2 hr water consumption. Bottom right panel: Intake of water during a 2-hour session on Day 3 of Phase 2 of Experiment 2 following injections of Veh, 6, 20 or 60 pmol of Ucn1. No significant differences between groups were found. The number of animals per group is shown in parenthesis.

Andrey E. Ryabinin, et al. Neuroscience. ;151(3):780-790.
4.
Figure 3

Figure 3. Dose dependent suppression of limited access ethanol and water consumption following microinjection of CRF into the lateral septum. From: Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

Top left panel: Baseline intake of 20% v/v ethanol during a 2-hour session on Day 2 of Phase 1 of Experiment 2 following sham injections in four groups of animals that were subsequently divided into dose groups. No significant differences between groups are observed in baseline 2 hr ethanol intake. Top right panel: Intake of 20% ethanol during a 2-hour session on Day 3 of Phase 1 of Experiment 2 following microinjections of vehicle (Veh), 6, 20 or 60 pmol of CRF. The highest dose of CRF significantly attenuated ethanol intake. Bottom left panel: Intake of water during a 2-hour session on Day 2 of Phase 2 of Experiment 2 following sham injections in four groups of animals that were subsequently divided into dose groups. No significant differences are observed in baseline 2 hr water intake. Bottom right panel: Intake of water during a 2-hour session on Day 3 of Phase 2 of Experiment 2 following injections of Veh, 6, 20 or 60 pmol of CRF. The highest dose of CRF significantly attenuated water intake. The number of animals per group is shown in parenthesis.

Andrey E. Ryabinin, et al. Neuroscience. ;151(3):780-790.
5.
Figure 5

Figure 5. Effects of repeated intra-lateral septum microinjection of Ucn1 on limited access ethanol consumption. From: Urocortin 1 microinjection into the mouse lateral septum regulates the acquisition and expression of alcohol consumption.

Top left panel: Intake of 20% v/v ethanol during 2-hour sessions on Days 1-3 of Experiment 4 following injections of 0 (vehicle), 0.1, 2 or 40 pmol of Ucn1. The highest dose of Ucn1 had suppressive effects on ethanol consumption. Top right panel: Intake of 20% ethanol during a 2-hour session following a sham injection on Day 4 of Experiment 4 (these animals had received 0, 0.1, 2 or 40 pmol of Ucn1 during the three days preceding Day 4, but not on Day 4). Animals with a history of repeated administration of 40 pmol of Ucn1 showed significantly lower intakes of ethanol. Bottom left panel: Intake of water during the 22 hours after the 2-hour ethanol drinking session during Days 1-3 of Experiment 4 (as a control for long-term effects of Ucn1). No significant differences between groups are observed. Bottom right panel: Intake of water during the 22 hours after the 2-hour ethanol drinking session following sham injections on Day 4 of Experiment 4. No significant effects are observed. The number of animals per group is shown in parenthesis (top panels).

Andrey E. Ryabinin, et al. Neuroscience. ;151(3):780-790.

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