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1.
Figure 1

Figure 1. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

A. Two dimensional gene cluster map representing 2,145 genes differentially regulated between day one patients with septic shock and control patients (see text for filtering strategy). Individual patients are oriented horizontally and individual genes are oriented vertically. The color-coded bar at the bottom of the map represents controls in gray and the patients with septic shock in black. Asterisks indicate patients having a viral etiology. B. Two dimensional gene cluster map representing 2,504 genes differentially regulated between day three patients with septic shock and control patients (see text for filtering strategy). The same conventions apply for Figure 1B as for that of Figure 1A.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.
2.
Figure 5

Figure 5. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

Representative gene network within the 1,283 genes downregulated on day one of pediatric septic shock. The gene network contains eight individual gene nodes corresponding to the major histocompatibility complex. The genes within the network correspond functionally to T cell activation, MHCII-mediated immunity, and MHC antigen (based on the Panther Classification System). See text for network derivation. A network legend and the entire gene list contributing to the network are provided in the supplementary data.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.
3.
Figure 4

Figure 4. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

Representative gene network within the 1,072 genes upregulated on day three of pediatric septic shock. The network is approximately centered on a gene node corresponding to Sp1 transcription factor (SP1). The genes within the network correspond functionally to the plasminogen activating cascade, immunity and defense, and complement component (based on the Panther Classification System). See text for network derivation. A network legend and the entire gene list contributing to the network are provided in the supplementary data.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.
4.
Figure 6

Figure 6. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

Two dimensional gene cluster map focused on the 1,283 downregulated genes on day one of septic shock (see text for filtering strategy). Individual patients are oriented horizontally and individual genes are oriented vertically. The color-coded bar at the bottom of the map represents the patients with septic shock grouped by quartiles of absolute lymphocyte counts (derived from Table 5) as follows: (turquoise) 1st quartile, (blue) 2nd quartile, (pink) 3rd quartile, (grey) 4th quartile; and (black) absolute lymphocyte count data not available.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.
5.
Figure 2

Figure 2. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

Comparison analysis of the signaling pathways corresponding to the 862 genes upregulated on day one and the 1,072 genes upregulated on day three of pediatric septic shock. The analysis is derived from the Ingenuity Pathways Analysis application (see text for details). The y-axis represents the -log (significance). For illustrative purposes, the x-axis crosses the y-axis at the 1.3 threshold of significance (i.e. -log (P value = 0.05) = 1.3). Significance is directly proportional to the number of genes within the data set that corresponds to the respective canonical signaling pathway, and inversely proportional to the number of genes in the entire data set uploaded to the Ingenuity Pathways Analysis application.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.
6.
Figure 3

Figure 3. From: Genome-Level Longitudinal Expression of Signaling Pathways and Gene Networks in Pediatric Septic Shock.

Comparison analysis of the signaling pathways corresponding to the 1,072 genes downregulated on day one and the 1,432 genes downregulated on day three of pediatric septic shock. The analysis is derived from the Ingenuity Pathways Analysis application (see text for details). The y-axis represents the -log (significance). For illustrative purposes, the x-axis crosses the y-axis at the 1.3 threshold of significance (i.e. -log (P value = 0.05) = 1.3). Significance is directly proportional to the number of genes within the data set that corresponds to the respective canonical signaling pathway, and inversely proportional to the number of genes in the entire data set uploaded to the Ingenuity Pathways Analysis application.

Thomas P Shanley, et al. Mol Med. 2007 Sep-Oct;13(9-10):495-508.

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