Results: 5

1.
Figure 2

Figure 2. Effect of SIV infection on neurotrophin mRNA expression in lymph nodes. From: SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins.

Real-time RT-PCR quantification of neurotrophin mRNAs in lymph nodes biopsied from uninfected (-) and SIV-infected (+) macaques. mRNA levels have been normalized to expression of housekeeping genes.

Erica K. Sloan, et al. Brain Behav Immun. ;22(2):185-194.
2.
Figure 4

Figure 4. Effect of in vitro SIV infection on neurotrophin expression by leukocytes. From: SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins.

Expression of NGF, BDNF, NT4 (a) and IFNG (b) in PBMC were quantified by real time RT-PCR. mRNA levels have been normalized to expression of housekeeping genes.

Erica K. Sloan, et al. Brain Behav Immun. ;22(2):185-194.
3.
Figure 3

Figure 3. Effect of SIV infection on neural inhibitor mRNA expression in lymph nodes. From: SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins.

Expression of IFNG, LIF and SEMA3C mRNA in lymph nodes from non-infected (-) and SIV-infected (+) macaques was quantified by real-time RT-PCR. mRNA levels have been normalized to expression of housekeeping genes.

Erica K. Sloan, et al. Brain Behav Immun. ;22(2):185-194.
4.
Figure 5

Figure 5. Model evaluating neuro-modulatory factors as mediators of SIV-induced denervation of lymphoid tissue. From: SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins.

Top p-value evaluates statistical significance of SIV effects on innervation density. Bottom p-value indicates statistical significance of residual effect of SIV infection on innervation density after controlling for variations in postulated mediators NGF, BDNF, NT4, and IFNG.

Erica K. Sloan, et al. Brain Behav Immun. ;22(2):185-194.
5.
Figure 1

Figure 1. Effect of SIV infection on lymph node sympathetic innervation. From: SIV infection decreases sympathetic innervation of primate lymph nodes: The role of neurotrophins.

Parenchymal catecholaminergic varicosities (arrowheads) were localized in lymph node sections using glyoxylic acid chemofluorescence (a). Immune cells are counterstained red. Sites of innervation were mapped (yellow dots) onto whole lymph node sections from non-infected (b) and SIV-infected rhesus macaques (c). SIV-infection was confirmed by in situ hybridization against viral gag, pol, and env genes (c, inset). Spatial stereological techniques quantified the density of innervation in non-infected and SIV-infected lymph nodes (d).

Erica K. Sloan, et al. Brain Behav Immun. ;22(2):185-194.

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