Results: 4

2.
Figure 3

Figure 3. From: A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with Autoimmune Polyglandular Syndrome Type 1.

IFN- a Ab assay results with and without competition for the five different patient groups. Shown are CPS results for individual samples with and without competition for IFN-α(8 μg/ml). Un: without competition assay results; C: competition assay results; NC: normal controls.

Li Zhang, et al. Clin Immunol. ;125(2):131-137.
3.
Figure 4

Figure 4. From: A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with Autoimmune Polyglandular Syndrome Type 1.

A) Competition assay of inhibition by different concentrations of fluid phase IFN-a protein (ranging from 0.0016 to 1.6 μg/ml) in the initial APS1 patient sample. Results are average CPS of duplicated wells. B) Scatchard plot of IFN-a protein binding to antibodies from the initial APS1 patient. The Scatchard analysis was performed with competition concentrations of IFN-a protein ranging from 0.0016 to 1.6 μg/ml. Results are the average of duplicate wells.

Li Zhang, et al. Clin Immunol. ;125(2):131-137.
4.
Figure 2

Figure 2. From: A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with Autoimmune Polyglandular Syndrome Type 1.

Index of IFN-a Ab’s in different patients groups. Anti-IFN a autoantibodies showed significant specificity in APS1 patients. Serum was diluted in 1:10 and measured by europium-based fluorescence. Each point presents the mean index of the duplicated well for that individual sample. The bar indicates the mean value for each cohort. APS1, n=7; non-APS1, n=6; normal controls, n=100; Addison’s Disease, n =71; Type 1 diabetes, n=141.

Li Zhang, et al. Clin Immunol. ;125(2):131-137.

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