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1.
Fig. 3

Fig. 3. From: AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish Study of High Density Schizophrenia Families (ISHDSF).

AKT gene expression relative to reference genes GAPDH and TBP analyzed by real-time qPCR of the Stanley Consortium brain series. Expression differences between diagnostic groups were evaluated by one-tailed Mann-Whitney U test for AKT1 (SCZ vs CONT) and two-tailed tests for all other comparisons.

Dawn L Thiselton, et al. Biol Psychiatry. ;63(5):449-457.
2.
Fig. 2

Fig. 2. From: AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish Study of High Density Schizophrenia Families (ISHDSF).

LD map of the AKT1 region in the ISHDSF. The map is viewed through Haploview v 3.2 (the solid spine rule for block structure is shown), with gene direction 3’–5’. Pairwise LD is indicated by the numbers (related to D’) and depth of red colour. SNPs and chromosomal positions are indicated along the top. The region spans ~26kb. Despite apparent ‘blocks’, the haplotypes on the right show no tag SNPs.

Dawn L Thiselton, et al. Biol Psychiatry. ;63(5):449-457.
3.
Fig. 1

Fig. 1. From: AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish Study of High Density Schizophrenia Families (ISHDSF).

Most significant AKT1 SNP haplotypes associated with schizophrenia to date. Exon locations of the 3 main alternative AKT1 transcripts are shown at the top (http://genome.ucsc.edu/, human genome build 35). SNPs are positioned underneath with intervening distances in kilobases. Numbers 1–8 refer to SNPs typed in our study. The p values of the most significant haplotypes are given for each report of association between AKT1 and schizophrenia. The arrows depict over-representation (up arrow) or under-representation (down arrow) in cases. SNP alleles highlighted in bold are significantly associated with schizophrenia as single SNPs. Marker order and haplotypes are given in the reverse order here to that in the text, in accordance with the orientation of the gene on the UCSC genome browser.

Dawn L Thiselton, et al. Biol Psychiatry. ;63(5):449-457.

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