Results: 5

1.
FIG. 2.

FIG. 2. From: Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia .

Crystal violet staining of viral plaques from TG homogenates 4 and 37 days after ocular inoculation with HSV-1. The inset is a magnified view of the single plaque from the “latently” infected mouse at 37 days p.i.

Todd P. Margolis, et al. J Virol. 2007 October;81(20):11069-11074.
2.
FIG. 3.

FIG. 3. From: Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia .

Immunostaining of viral plaques from TG homogenates 4 and 37 days after ocular inoculation with HSV-1. The inset is a magnified view of the single HSV-1 antigen-positive plaque from the “latently” infected mouse at 37 days p.i.

Todd P. Margolis, et al. J Virol. 2007 October;81(20):11069-11074.
3.
FIG. 5.

FIG. 5. From: Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia .

Immunohistochemical staining of TG 37 days after ocular inoculation with either HSV-1 KOS (left) or HSV-1 KOS dl1.8 (right). As assayed in this manner, the rate of spontaneous reactivation of these two viruses was similar. Bar, 100 μm.

Todd P. Margolis, et al. J Virol. 2007 October;81(20):11069-11074.
4.
FIG. 4.

FIG. 4. From: Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia .

Confocal images of a spontaneously reactivating neuron in a latently infected mouse trigeminal ganglion. (A) Nuclear staining with TO-PRO-3-iodide. (B) Neuronal specific staining with anti-NeuN antisera. (C) Staining of productively infected neuron with HSV-1 specific antisera. (D) Merged image. Bar, 100 μm.

Todd P. Margolis, et al. J Virol. 2007 October;81(20):11069-11074.
5.
FIG. 1.

FIG. 1. From: Spontaneous Reactivation of Herpes Simplex Virus Type 1 in Latently Infected Murine Sensory Ganglia .

Immunohistochemical staining of TG 37 days postinoculation. Four examples of HSV-1 antigen staining in “latently' infected tissue. (A) HSV-1 antigen-positive neuron. (B) HSV-1 antigen and apoptotic cellular material surrounded by inflammatory cells. (C and D) HSV-1 antigen and cellular debris in foci of inflammation. These images suggest that not only are viral proteins expressed in rare neurons of “latently” infected ganglia but also that this process is associated with cellular destruction and subsequent spread to adjacent cells (glia and white blood cells). Bar, 50 μm.

Todd P. Margolis, et al. J Virol. 2007 October;81(20):11069-11074.

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