Results: 5

1.
Figure 2

Figure 2. From: Evolutionary conservation of regulated longevity assurance mechanisms.

Protein synthesis and GST activity are potential semi-public determinants of longevity.

Joshua J McElwee, et al. Genome Biol. 2007;8(7):R132-R132.
2.
Figure 3

Figure 3. From: Evolutionary conservation of regulated longevity assurance mechanisms.

Cellular detoxification (drug metabolism). This process entails two phases: phase 1 (functionalization reactions), and phase 2 (conjugative reactions), which are carried out by several large and diverse gene families, including the CYPs, SDRs and GSTs.

Joshua J McElwee, et al. Genome Biol. 2007;8(7):R132-R132.
3.
Figure 4

Figure 4. From: Evolutionary conservation of regulated longevity assurance mechanisms.

Phylogenetic tree of the GST gene families from worms, flies, and mice. Genes from each species are color-coded, and significantly (q < 0.1) differentially expressed genes in each dataset are shown by closed (up-regulated) or open (down-regulated) circles (see Additional data file 2 for phylogenetic trees for GST, CYP, SDR, and UGT gene families).

Joshua J McElwee, et al. Genome Biol. 2007;8(7):R132-R132.
4.
Figure 5

Figure 5. From: Evolutionary conservation of regulated longevity assurance mechanisms.

Different determinants of longevity may be public, semi-public or private. Our results suggest that public regulators of lifespan regulate semi-public mechanisms of longevity assurance, which may in turn act on a combination of private and public mechanisms of aging. The semi-public character of longevity assurance processes is reflected by the IIS-regulated gene classes. Several are linked to detoxification (such as the GSTs), and are the results of copious lineage-specific expansions.

Joshua J McElwee, et al. Genome Biol. 2007;8(7):R132-R132.
5.
Figure 1

Figure 1. From: Evolutionary conservation of regulated longevity assurance mechanisms.

Overlap of differentially expressed functional categories in long-lived nematodes, fruitflies and mice. These Venn diagrams show the number and overlap of significantly differentially regulated functional categories (p < 0.05; GO categories and Interpro domain families) identified in each dataset using Catmap. While most of the differentially expressed categories in each dataset are species-specific, a small number of categories (boxed) show significant changes in expression in response to reduced IIS in all three species. These categories are detailed in Table 5.

Joshua J McElwee, et al. Genome Biol. 2007;8(7):R132-R132.

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