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Results: 5

1.
<b>Figure 4.</b>

Figure 4.. From: Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis.

Airway-associated collagen content in bleomycin-treated mice. (A) Photomicrographs depicting representative airways selected for analysis of subepithelial collagen thickness and the eight-point spoke wheel centered within each airway. (B) Subepithelial collagen thickness around small- to medium-sized airways did not differ among bleomycin-treated groups (n = 13–16 per group).

Jeffrey W. Card, et al. Am J Respir Cell Mol Biol. 2007 September;37(3):300-308.
2.
<b>Figure 3.</b>

Figure 3.. From: Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis.

Bleomycin-induced alterations in lung mechanics were exaggerated in COX-2 null mice and reversed by airway COX-1 overexpression in transgenic mice. (A) Changes in Cst relative to saline-treated mice of the same genotype (n = 13–16 per group). (B) Changes in E relative to saline-treated mice of the same genotype (n = 13–16 per group). (C) Changes in H relative to saline-treated mice of the same genotype (n = 13–16 per group). *P < 0.05 versus all other groups; #P < 0.05 versus COX-2 null.

Jeffrey W. Card, et al. Am J Respir Cell Mol Biol. 2007 September;37(3):300-308.
3.
<b>Figure 5.</b>

Figure 5.. From: Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis.

BAL fluid prostaglandin and cysLT levels in bleomycin-treated mice. (A) Airway prostaglandin levels in saline-treated mice (n = 3–4 per group). (B) Airway prostaglandin levels in bleomycin-treated mice. Levels did not differ between COX-2 WT and COX-2 null mice, and levels of PGF, PGD2 and PGE2 were increased by airway COX-1 overexpression in transgenic mice (n = 11–12 per group). *P < 0.05 versus COX-2 WT and COX-2 null. (C) Airway cysLT levels in saline-treated mice (n = 5–7 per group). (D) Airway cysLT levels in bleomcyin-treated mice. Airway cysLT levels were increased in COX-2 null mice and reduced by airway COX-1 overexpression in transgenic mice (n = 9–12 per group). *P < 0.05 versus COX-2 WT.

Jeffrey W. Card, et al. Am J Respir Cell Mol Biol. 2007 September;37(3):300-308.
4.
<b>Figure 2.</b>

Figure 2.. From: Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis.

Bleomycin-induced lung fibrosis was not altered by airway COX-1 overexpression in transgenic mice. (A) BAL fluid cells in saline- and bleomycin-treated mice (n = 7–11 in saline groups and 18–19 in bleomycin groups). (B) Representative histologic sections of lung tissue stained with Masson's trichrome. (C) Calculated fibrosis scores based on histopathologic assessment of trichrome-stained lung sections (n = 5–7 in saline groups and 10–12 in bleomycin groups). (D) Lung collagen content in saline- and bleomycin-treated mice (n = 5–7 in saline groups and 10–12 in bleomycin groups). *P < 0.05 versus saline-treated mice of the same genotype.

Jeffrey W. Card, et al. Am J Respir Cell Mol Biol. 2007 September;37(3):300-308.
5.
<b>Figure 1.</b>

Figure 1.. From: Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis.

Bleomycin-induced lung fibrosis was not altered in COX-2 null mice. (A) BAL fluid cells in saline- and bleomycin-treated mice (n = 9–11 in saline groups and 18–20 in bleomycin groups). (B) Representative histologic sections of lung tissue stained with Masson's trichrome. (C) Calculated fibrosis scores based on histopathologic assessment of trichrome-stained lung sections (n = 6–7 in saline groups and 12 in bleomycin groups). (D) Lung collagen content in saline- and bleomycin-treated mice (n = 6–7 in saline groups and 12 in bleomycin groups). *P < 0.05 versus saline-treated mice of the same genotype.

Jeffrey W. Card, et al. Am J Respir Cell Mol Biol. 2007 September;37(3):300-308.

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