Results: 2

1.
Fig. 1.

Fig. 1. From: Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.

Diagram of AIP displaying the presumably pathogenic mutations identified in this study. The locations of the FKBP-homology region and the three tetratricopeptide repeats (TPRs) are indicated by colored boxes. AHR and HSP90 interaction regions are indicated by black lines.

Marianthi Georgitsi, et al. Proc Natl Acad Sci U S A. 2007 March 6;104(10):4101-4105.
2.
Fig. 2.

Fig. 2. From: Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.

AIP IHC. (A) AIP immunoreaction is observed in both the cytoplasm and the nucleus in normal adenohypophysis. (B) AIP expression in AIP-proficient adenoma. (C and D) AIP-deficient adenomas from two acromegaly patients bearing the p.Q14X mutation. There is complete loss of immunoreaction in adenoma cells, whereas AIP heterozygous peripheral blood leucocytes display positive immunoreaction, indicated by black arrows.

Marianthi Georgitsi, et al. Proc Natl Acad Sci U S A. 2007 March 6;104(10):4101-4105.

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