Display Settings:

Items per page
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 12

1.
FIG. 12.

FIG. 12. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Uniformity and diversity of membrane lipids.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
2.
FIG. 4.

FIG. 4. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Synthetic pathway of polyprenyl diphosphate. PP in the structural formula is pyrophosphate.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
3.
FIG. 11.

FIG. 11. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Proposed biosynthetic route of tetraether lipids in Thermoplasma acidophilum inferred from inhibition experiments with terbinafine (73).

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
4.
FIG. 3.

FIG. 3. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Expectation of 13C incorporation from [13CH3]acetate into GGPP via the MVA pathway (18, 28). PP in the structural formula is pyrophosphate.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
5.
FIG. 6.

FIG. 6. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Glycerol metabolism and lipid biosynthesis in archaea. The reactions indicated with open arrows are the catabolic pathway of glycerol in heterotrophic archaea. Reactions shown with closed arrows are the synthetic pathway of phospholipid in archaea (79).

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
6.
FIG. 1.

FIG. 1. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Characteristics of archaeal polar lipids. Archaeal phospholipids are characterized by (i) G-1-P backbone, (ii) ether bonds, (iii) isoprenoid hydrocarbon chains, and (iv) bipolar tetraether lipids. Most of the polar head groups of phospholipids are shared by archaea and bacteria.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
7.
FIG. 5.

FIG. 5. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Three possible reactions for the direct formation of G-1-P: A, reduction of d-GAP; B, reduction of DHAP; C, phosphorylation of glycerol (G-1-P forming). Enzyme 1, glycerol kinase (G-3-P forming); enzyme 2, G-3-P dehydrogenase; enzyme 3, triose phosphate isomerase; enzyme 4, G-1-P dehydrogenase. Reaction 5, ether lipid synthesis. FDP, fructose diphosphate.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
8.
FIG. 7.

FIG. 7. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Phylogenetic tree of G-1-P dehydrogenase and its homologs. The sequence is indicated by the source name of the sequence database (sp, SwissProt; pir, PIR; gb, GenBank; pdb, PDB) and the identification code. G1PDH, sn-glycerol-1-phosphate dehydrogenase; GDH, glycerol dehydrogenase; DHQS, dehydroquinate synthase; ALDH, alcohol dehydrogenase type IV. (Reprinted from reference 16 by permission of Oxford University Press.)

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
9.
FIG. 9.

FIG. 9. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Phylogenetic tree of archaetidylserine synthase and phosphatidylserine synthase constructed by the maximum-likelihood method. The sequence is indicated by the source name and GI number from the National Center for Biotechnology Information. PSD-A and PSD-B are two groups (A and B) of phosphatidylserine decarboxylase that are divided by phylogenetic analysis (17). (Reprinted from reference 17 by permission of the publisher.)

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
10.
FIG. 2.

FIG. 2. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

MVA pathway for synthesis of isopentenyl diphosphate and dimethylallyl diphosphate. 1, acetyl-CoA acetyltransferase; 2, HMG-CoA synthase; 3, HMG-CoA reductase; 4, MVA kinase; 5, phosphomevalonate kinase; 6, diphosphomevalonate decarboxylase; 7, isopentenyl diphosphate isomerase; 8, hypothetical phosphomevalonate decarboxylase; 9, isopentenyl phosphate kinase. The classical MVA pathway proceeds from reaction 1 through reaction 7 via reactions 5 and 6, while a modified MVA pathway goes through reactions 8 and 9 (33). P and PP in the structural formula are phosphate and pyrophosphate, respectively.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
11.
FIG. 10.

FIG. 10. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Phylogenetic tree of archaetidylinositol synthase and archaetidylglycerol synthase constructed by the maximum-likelihood method. The sequence is indicated by the source name and GI number from the National Center for Biotechnology Information. The presence or absence of archaetidylinositol (AI) or archaetidylglycerol (AG)/archaetidylglycerophosphate (AGP) in each species is indicated by a symbol, “+” or “−,” after the source name and GI number. The symbol “?” indicates that the lipid composition has not been reported for the species. For the characters “A,” “B,” “C,” and “X,” see reference 17. PIS, phosphatidylinositol synthase; PGS, phosphatidyglycerol synthase; AIS, archaetidylinositol synthase; AGS, archaetidylglycerol synthase. (Reprinted from reference 17 by permission of the publisher.)

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.
12.
FIG. 8.

FIG. 8. From: Biosynthesis of Ether-Type Polar Lipids in Archaea and Evolutionary Considerations.

Possible biosynthetic pathway for phospholipids in archaea compared with their bacterial counterpart. Enzymes confirmed by in vitro experiments are as follows: 1, G-1-P dehydrogenase; 2, GGGP synthase; 3, DGGGP synthase; 4, CDP-archaeol synthase; 5, archaetidylserine synthase. Reactions and enzymes 6 to 9 are indicated by in vivo experiments or database searches of the relevant genes. 6, archaetidylserine decarboxylase; 7, archaetidylinositol synthase; 8, archaetidylglycerophosphate synthase; 9, archaetidylglycerophosphate phosphatase. The established enzymes for phospholipid biosynthesis in bacteria are as follows; 1′, G-3-P dehydrogenase; 2′, lysophosphatidic acid synthase; 3′, phosphatidic acid synthase; 4′, CDP-diacylglycerol synthase; 5′, phosphatidylserine synthase; 6′, phosphatidylserine decarboxylase; 7′, phosphatidylinositol synthase; 8′, phosphatidylglycerophosphate synthase; 9′, phosphatidylglycerophosphate phosphatase. P and PP in the structural formula are phosphate and pyrophosphate, respectively.

Yosuke Koga, et al. Microbiol Mol Biol Rev. 2007 March;71(1):97-120.

Display Settings:

Items per page

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk