We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 4

1.
Figure 1

Figure 1. From: Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.

Functional domains of NF1. Mouse NF1 is more than 98.5% identical to its human homologue. Both contain the p120Ras-GRD, which accelerates the conversion of the active, GTP-bound Ras into its inactive GDP-bound form.

LQ Le, et al. Oncogene. ;26(32):4609-4616.
2.
Figure 2

Figure 2. From: Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.

Representation of NF1 interactions with the Ras and PI3K pathways. NF1 constrains Ras activity in the normal cell. Therefore, loss of NF1 expression leads to elevated Ras activity, dysregulated cell growth and tumorigenesis. NF1 may also associate with microtubules and modulate the cAMP-PKA signaling pathway.

LQ Le, et al. Oncogene. ;26(32):4609-4616.
3.
Figure 4

Figure 4. From: Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.

The possible interactions between NF1 heterozygous (abnormal) local cells within the neurofibroma tumor microenvironment. NF1+/− mast cells could be recruited to the site by the NF1−/− Schwann cells via chemoattractant such as SCF. Once in place, the mast cells may selectively secrete factors such as mitogens to initiate tumorigenesis, angiogenic molecules to promote neovascularization or TGF-β to stimulate collagen production for extracellular matrix remodeling.

LQ Le, et al. Oncogene. ;26(32):4609-4616.
4.
Figure 3

Figure 3. From: Tumor microenvironment and neurofibromatosis type I: connecting the GAPs.

Schwann cell origin and the role of tumor microenvironment in neurofibroma formation. Both nullizygosity at NF1 locus in Schwann cells and haploinsufficiency of NF1 in the somatic tissue are required for neurofibroma tumorigenesis. In addition, the NF1-heterozygous mast cells infiltration into nerve tissues precedes development of NF1flox/−;Krox20-Cre plexiform neurofibromas, implying a unique affinity between NF1−/− Schwann cells and NF1+/− mast cells and a causal role for mast cells in tumor initiation.

LQ Le, et al. Oncogene. ;26(32):4609-4616.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk