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1.
Figure 2

Figure 2. From: Acetaminophen and Diphenhydramine Premedication for Allergic and Febrile Non-hemolytic Transfusion Reactions: Good Prophylaxis or Bad Practice?.

Febrile transfusion reactions according to the number of previous transfusion reactions and premedications used. Febrile nonhemolytic transfusion reactions are uncommon, even when a patient has had 2 or more previous febrile reactions. The rate of reaction is not affected by premedication with diphenhydramine or acetaminophen (p-value not significant for any subgroup versus any other).3

Terrence L. Geiger, et al. Transfus Med Rev. ;21(1):1-12.
2.
Figure 1

Figure 1. From: Acetaminophen and Diphenhydramine Premedication for Allergic and Febrile Non-hemolytic Transfusion Reactions: Good Prophylaxis or Bad Practice?.

Allergic transfusion reactions according to the number of previous transfusion reactions and premedications used. Allergic transfusion reactions are uncommon, even when a patient has had 2 or more previous allergic transfusion reactions. The rate of reaction is not affected by premedication with diphenhydramine or acetaminophen (p-value not significant for any subgroup versus any other).3

Terrence L. Geiger, et al. Transfus Med Rev. ;21(1):1-12.
3.
Figure 3

Figure 3. From: Acetaminophen and Diphenhydramine Premedication for Allergic and Febrile Non-hemolytic Transfusion Reactions: Good Prophylaxis or Bad Practice?.

Pre-medication doses needed to prevent one transfusion reaction. The number of premedication doses needed to prevent a single transfusion reaction is displayed as a function of the baseline risk of transfusion reaction and the percentage reduction in the incidence of reaction when premedication is used. No study has shown that premedication reduces the rate of febrile non-hemolytic or allergic transfusion reactions, so the true reduction in reaction incidence may be zero.

Terrence L. Geiger, et al. Transfus Med Rev. ;21(1):1-12.

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