Results: 5

1.
Scheme 1

Scheme 1. From: Oxidative Metabolism of Seleno-L-Methionine to L-Methionine Selenoxide by Flavin- Containing Monooxygenases.

Scheme of the oxidation of seleno-L-methionine to seleno-L-methionine selenoxide by FMOs.

Renee J. Krause, et al. Chem Res Toxicol. ;19(12):1643-1649.
2.
Figure 3

Figure 3. From: Oxidative Metabolism of Seleno-L-Methionine to L-Methionine Selenoxide by Flavin- Containing Monooxygenases.

Time-dependent formation of MetSeO by cDNA-expressed human FMO1 and FMO3.

Renee J. Krause, et al. Chem Res Toxicol. ;19(12):1643-1649.
3.
Figure 4

Figure 4. From: Oxidative Metabolism of Seleno-L-Methionine to L-Methionine Selenoxide by Flavin- Containing Monooxygenases.

Nonlinear curve fitting plot of L-methionine selenoxide formation by purified rat liver FMO1 (A) and FMO3 (B).

Renee J. Krause, et al. Chem Res Toxicol. ;19(12):1643-1649.
4.
Figure 2

Figure 2. From: Oxidative Metabolism of Seleno-L-Methionine to L-Methionine Selenoxide by Flavin- Containing Monooxygenases.

Representative time course (A), protein dependence (B) and nonlinear curve fitting plot (C) of MetSeO formation by rat liver microsomes. Details on experimental conditions can be found in the Materials and Methods.

Renee J. Krause, et al. Chem Res Toxicol. ;19(12):1643-1649.
5.
Figure 1

Figure 1. From: Oxidative Metabolism of Seleno-L-Methionine to L-Methionine Selenoxide by Flavin- Containing Monooxygenases.

A typical reverse-phase HPLC chromatogram of the reaction mixture of SeMet (5 mM) with rat liver microsomes (1 mg/mL) in the absence (A) and presence (B) of NADPH following derivatization with 2,4-dinitrofluorobenzene, showing the N-2,4- dinitrophenyl derivatives of MetSeO (I) and SeMet (II). The incubation time was 20 min.

Renee J. Krause, et al. Chem Res Toxicol. ;19(12):1643-1649.

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