Results: 2

1.
FIGURE 1

FIGURE 1. From: IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells.

Changes in circulating levels of hematopoietic cells in patients receiving IL-7. Each line represents an individual patient. A, Absolute neutrophil (filled symbols) and absolute lymphocyte (empty symbols) counts. B, CD4+ (filled symbols) and CD8+ (empty symbols) cells. C, CD4/CD8 ratio for each patient.

Steven A. Rosenberg, et al. J Immunother. ;29(3):313-319.
2.
FIGURE 2

FIGURE 2. From: IL-7 Administration to Humans Leads to Expansion of CD8+ and CD4+ Cells but a Relative Decrease of CD4+ T-Regulatory Cells.

Peripheral blood mononuclear cells from 3 patients (60 λμg/kg dose) (A) were stained with fluorescein isothiocynate-conjugated CD4, PerCP-conjugated CD3, and APC-conjugated CD25 antibodies followed by intracellular staining with biotinylated Foxp3 antibody. The dot plots were gated on CD3+ T lymphocytes. B, Peripheral blood mononuclear cells from these patients were also stained with fluorescein isothiocynate-conjugated CD4, PE-conjugated CD25, and antigen presenting cells-conjugated CD127 (IL-7Rαchain) followed by intracellular staining for Foxp3 protein. The dot plots were gated on CD3+CD4+ T cells. The quadrants were set based on isotype control antibodies as well as negative control, and the numbers represent the percentage of cells in each quadrant.

Steven A. Rosenberg, et al. J Immunother. ;29(3):313-319.

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