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Results: 4

1.
Figure 1

Figure 1. From: The Comparative Toxicogenomics Database (CTD): A Cross-Species Resource for Building Chemical-Gene Interaction Networks.

High Level View of the Primary Data Types in CTD.

Carolyn J. Mattingly, et al. Toxicol Sci. ;92(2):587-595.
2.
Figure 2

Figure 2. From: The Comparative Toxicogenomics Database (CTD): A Cross-Species Resource for Building Chemical-Gene Interaction Networks.

Overview of CTD information retrieval process. White objects represent manual or automated processes. Dark grey objects represent physical objects (files or databases).

Carolyn J. Mattingly, et al. Toxicol Sci. ;92(2):587-595.
3.
Figure 3

Figure 3. From: The Comparative Toxicogenomics Database (CTD): A Cross-Species Resource for Building Chemical-Gene Interaction Networks.

Sample CTD Chemical Detail Page. The CTD chemical detail page provides a description, synonyms and CAS name, a chemical structure drawing, links to supplemental data in other databases such as microarray data, and access to associated genes and references in CTD.

Carolyn J. Mattingly, et al. Toxicol Sci. ;92(2):587-595.
4.
Figure 4

Figure 4. From: The Comparative Toxicogenomics Database (CTD): A Cross-Species Resource for Building Chemical-Gene Interaction Networks.

Chemical-Gene Interaction Network Schematic. Cross-species interactions between chemicals and genes and proteins are curated manually from the literature for CTD. These data will be important for building complex interaction networks. This high-level schematic represents specific interactions that have been curated between lipopolysaccharides (LPS) and 286 genes and proteins, as well as integration with other relevant data such as associated diseases. A list of these genes and proteins are provided as supplementary data. Curated interaction data will be integrated with the CTD web interface in future releases. Square, unique genes and proteins (not a one:one ratio); circle, chemical; rounded rectangle, CTD interactions; shadowed rectangle, associated data (e.g., diseases associated with LPS); arrowed lines, activation; bullet lines, inhibition (e.g., LPS activates expression of 152 genes and inhibits activity of 4 proteins).

Carolyn J. Mattingly, et al. Toxicol Sci. ;92(2):587-595.

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