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1.
FIG. 2.

FIG. 2. From: Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis.

Effect of different treatment regimens on survival of persistently leukopenic rats with invasive pulmonary aspergillosis (Kaplan-Meier plot). Each group consisted of 15 animals. Control animals received no treatment (dashed line). Treatment was started at 16 h after fungal inoculation, at which time mycelial growth begins. Animals were treated with intravenous AMB-DOC (○), intravenous AMB-DOC in combination with aerosolized L-AMB (•), aerosolized L-AMB (*), intravenous L-AMB (□), intravenous L-AMB in combination with aerosolized L-AMB (▪), intravenous AMB-DOC plus L-AMB (▵), or intravenous AMB-DOC plus L-AMB in combination with aerosolized L-AMB (▴).

Elisabeth J. Ruijgrok, et al. Antimicrob Agents Chemother. 2006 May;50(5):1852-1854.
2.
FIG. 1.

FIG. 1. From: Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis.

Localization of nebulized colloidal gold-labeled liposomes in infected lung tissue. (a) Localization of silver-enhanced colloidal gold-labeled liposomes in alveoli is visualized as black dots (arrows). The liposomes are deposited at the alveolar epithelium. The alveolar epithelium consists of alveolar type I and type II epithelium cells, which are identified, as well as blood vessels. The counterstain is hematoxylin and eosin. (b) Liposomes deposited in the alveolar sacs and ducts are partially internalized by alveolar macrophages (black clusters indicated by arrows). (c) Grocott methenamine stain of pulmonary tissue at 30 h after inoculation of 1.5 × 105 Aspergillus conidia. The conidia are inoculated deep in the left lung lobe, internalized by pulmonary epithelial tissue and germinated into hyphae at this time. (d) Silver-enhanced colloidal gold-labeled liposomes are deposited in and around pulmonary tissue (arrows). The counterstain is hematoxylin and eosin. Leukocytes are identified as purple cells. The section is adjacent to that shown in Fig. 1c.

Elisabeth J. Ruijgrok, et al. Antimicrob Agents Chemother. 2006 May;50(5):1852-1854.

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