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1.
FIG. 2.

FIG. 2. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Immunofluorescence study of binding of MAbs F598 and F628 to wild-type (WT) and Δica S. aureus strain Mn8, showing specificity of binding to the PNAG-producing parental strain.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
2.
FIG. 3.

FIG. 3. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Relative deposition onto purified PNAG of the third component of complement (C3) by IgG1 (filled symbols) and IgG2 (open symbols) MAbs. C3 deposition was measured by ELISA with a goat anti-human C3. The MAb to alginate is an irrelevant human IgG1 antibody specific for the P. aeruginosa alginate capsular antigen.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
3.
FIG. 6.

FIG. 6. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Protection against S. aureus strain Reynolds with IgG1 MAbs (12 mice per group). (A) A 600-μg volume of each MAb was administered 4 h before bacterial challenge. (B) A 300-μg volume of each MAb was administered 4 h before bacterial challenge. Challenge dose, 2.5 × 108 CFU/mouse; *, P value less than 0.05 compared to IgG1 control MAb.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
4.
FIG. 4.

FIG. 4. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Opsonophagocytic activity of IgG1 and IgG2 MAbs. Target strain is S. aureus Mn8. Bars represent means; error bars represent the standard errors of the means for three to eight replicates. Percent reduction in CFU was calculated compared to controls containing complement, PMNs, bacteria, and IgG control antibodies.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
5.
FIG. 1.

FIG. 1. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

ELISA reactivities of IgG1 (A and B) and IgG2 (C and D) MAbs to PNAG (A and C) and dPNAG (B and D) antigens. (A) Binding of isotype-switched IgG1 MAbs F598, F628, and F630 to native PNAG. (B) Binding of IgG1 MAbs to dPNAG antigen. (C) Binding of IgG2 MAbs to PNAG antigen. (D) Binding of IgG2 MAbs to dPNAG antigen. The irrelevant antibody is a human IgG1 antibody specific for P. aeruginosa alginate.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
6.
FIG. 7.

FIG. 7. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Protection against S. aureus MN8 lethal infection with IgG1 MAbs to PNAG (eight mice per group). (A) A 400-μg volume of each MAb was administered 4 h before challenge. Strain Mn8 challenge dose, 5 × 108. (B) A 200-μg volume of each MAb was administered 4 h before challenge. Strain Mn8 challenge dose, 9 × 108; *, P value less than 0.05 compared to IgG1 control MAb.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.
7.
FIG. 5.

FIG. 5. From: Characterization of the Opsonic and Protective Activity against Staphylococcus aureus of Fully Human Monoclonal Antibodies Specific for the Bacterial Surface Polysaccharide Poly-N-Acetylglucosamine .

Opsonophagocytic killing of several staphylococcal strains with MAb F598 at 12 μg/ml. Bars represent means; error bars represent the standard errors of the means. S. aureus strains Mn8, Newman, 10833, and Reynolds and S. epidermidis strain M187 represent methicillin-sensitive clinical and laboratory isolates. Strain 123 (also designated MW2 or USA400) is an MRSA strain carrying the PVL genes whose genome has been sequenced. Strains 192 and 193 represent MRSA, PVL-positive isolates from community-acquired infections. Strain 157 is a methicillin-sensitive, PVL-positive S. aureus isolate from a patient with lethal necrotizing pneumonia.

Casie Kelly-Quintos, et al. Infect Immun. 2006 May;74(5):2742-2750.

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