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Results: 6

1.
Figure 3

Figure 3. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of UFP-101 (0, 5.0, 10.0, and 20.0 μg/rat) on ethanol intake in Marchigian Sardinian alcohol-preferring rats. The drug was given intracerebroventricular twice at 95 and 15 min before ethanol access, and alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (± SEM) of seven subjects. Difference from control subjects was not statistically significant. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.
2.
Figure 2

Figure 2. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of intraperitoneal injection of naltrexone (Ntx) (0, .25, 1.0, and 2.5 mg/kg) on ethanol intake in Marchigian Sardinian alcohol-preferring rats. Drug injections were given 95 min before ethanol access, and alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (±SEM) of 10 subjects. Difference from control subjects: *p <.05. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.
3.
Figure 1

Figure 1. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of intraperitoneal injection of buprenorphine (Bup) (0, .03, .3, 3.0, and 6.0 mg/kg) on ethanol intake in Marchigian Sardinian alcohol-preferring rats. The drug was given 90 min before ethanol access, and alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (±SEM) of 10 subjects. Difference from control subjects: *p < .05; **p < .01. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.
4.
Figure 6

Figure 6. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of intracerebroventricular (ICV) injection of UFP-101, at doses ineffective per se (10.0, 20.0 μg/rat), on buprenorphine-induced decreased ethanol intake (3.0 mg/kg) in Marchigian Sardinian alcohol-preferring rats. The UFP-101 was ICV injected 95 and 15 min before access to ethanol. Buprenorphine (Bup) was given 90 min before access to ethanol. Alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (±SEM) of 10 subjects. Difference from control subjects: *p < .05. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.
5.
Figure 4

Figure 4. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of intraperitoneal (IP) injection of naltrexone (Ntx), at a dose ineffective per se (.25 mg/kg), on buprenorphine-induced increased ethanol intake (.03 mg/kg) in Marchigian Sardinian alcohol-preferring rats. Buprenorphine (Bup) was injected IP 5 min after Ntx administration, and ethanol was given to the animals 90 min after Bup. Alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (±SEM) of 10 subjects. Difference from control subjects: *p < .05. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.
6.
Figure 5

Figure 5. From: Buprenorphine Reduces Alcohol Drinking Through Activation of the Nociceptin/Orphanin FQ-NOP Receptor System.

Effect of intraperitoneal (IP) injection of naltrexone (Ntx), at a dose ineffective per se (.25 mg/kg), on buprenorphine-induced decreased ethanol intake (3.0 mg/kg) in Marchigian Sardinian alcohol-preferring rats. Five minutes after Ntx administration animals received an IP injection of buprenorphine (Bup), and ethanol was given to the animals 90 min after Bup. Alcohol consumption was monitored at 30, 60, 90, and 120 min. Values represent the mean (± SEM) of eight subjects. Difference from control subjects: *p < .05. Veh, vehicle.

Roberto Ciccocioppo, et al. Biol Psychiatry. ;61(1):4-12.

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