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Results: 4

1.
<b>Figure 2</b>

Figure 2. From: Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.

 Pedigrees of families 1 and 2, showing haplotypes for chromosome 10q23 microsatellite markers. Asterisks denote individuals in family 1 who were genotyped by the high throughput SNP array. Closed, grey, and open symbols denote affected, unknown, and unaffected individuals, respectively. Boxed haplotype denotes the putative disease haplotype. The letter “r” besides the allele refers to recombination. Haplotypes for individuals 1 and 3 from family 1 and individual 1 from family 2 were inferred.

X Cao, et al. J Med Genet. 2006 March;43(3):e13-e13.
2.
<b>Figure 1</b>

Figure 1. From: Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.

 Multiple polyps of mixed morphology in individual 2 of family 1 (A–C) and individual 4 of family 2 (D–F). Panels (A–B) show sections of a mixed hyperplastic‐juvenile polyp featuring (A) dilated, non‐dysplastic glands (×40, original magnification) and (B) hyperplastic glands (×100, original magnification); panel (C) shows a separate mixed adenomatous‐hyperplastic polyp and hyperplastic glands with serrated lumina indicated with an arrow (×100, original magnification). Panels (D–E) show sections of a mixed hyperplastic‐juvenile polyp featuring (D) a dilated, non‐dysplastic juvenile type gland (arrow) (×100, original magnification) and (E) a hyperplastic gland (arrow) with a serrated lumen (×100, original magnification); panel (F) shows a separate tubular adenoma with mildly dysplastic surface tubular glands (arrow) (×100, original magnification).

X Cao, et al. J Med Genet. 2006 March;43(3):e13-e13.
3.
<b>Figure 4</b>

Figure 4. From: Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.

 Mutation in BMPR1A causes HMPS. (A) The list of SNPs, microsatellite (MS) markers, and characterised genes in the critical interval of 83–90 Mb on 10q23. Genes in bold are genes with OMIM identification. (B) Sequence analysis showing BMPR1A 11 bp deletion at codon 43. (C) All affected individuals (asterisks) of family 2 show both homoduplex and heteroduplex bands of the amplified 240 and 229 bp fragments while all unaffected individuals exhibit the 240 bp homoduplex bands only when run on a 8% polyacrylamide gel.

X Cao, et al. J Med Genet. 2006 March;43(3):e13-e13.
4.
<b>Figure 3</b>

Figure 3. From: Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function.

 Genomewide (A) and chromosome 10q23 (B) linkage analyses. (A) SNP genotyping and haplotype based linkage analysis by Varia reveal a 7 Mb region on chromosome 10 (83–90 Mb) with LOD scores above 2.0. Each haplotype block contains a list of possible haplotypes as well as a pattern of co‐transmission among the individuals (black lines) genotyped. The maximum haplotype based LOD score is 2.664 (θ = 0) at 84 Mb. (B) A sliding map of nine microsatellite markers was used to calculate multipoint linkage analysis between markers D10S569 and D10S536. Combined genotyping data from families 1 and 2 were used.

X Cao, et al. J Med Genet. 2006 March;43(3):e13-e13.

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