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Results: 7

1.
Figure 6

Figure 6. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Viability of KB-3-1 cells treated in tissue culture with PE38 packaged in vitro and doxorubicin. 105 KB-3-1 cells were transduced with PE38 plasmid DNA packaged in vitro (dark blue), and the number of cells was compared to mock transduced cells (magenta). Other treatments on transduced cells were as follows: 105 KB-3-1 cells treated with 6 ng/ml (green), 105 KB-3-1 cells treated with 12 ng/ml (light blue), 105 KB-3-1 cells transduced with PE38 plasmid DNA packaged in vitro (purple), and treated with 6 ng/ml, and 105 KB-3-1 cells transduced with PE38 plasmid DNA packaged in vitro (brown), and treated with 12 ng/ml. Cells were counted every 2-3 days in order to monitor their viability.

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
2.
Figure 5

Figure 5. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Tissue fluorescence of EGFP packaged in vitro and control mice treated intraperitoneally several days post tumor challenge. Treatment was followed three days after mice were inoculated with 2 × 106 KB-3-1 cells. Tumor size as well as mouse weight were followed for 30 days. Figure 5 shows five different tissues (from the top) kidney, heart, liver, spleen and tumor of IVP-EGFP (left) and PBS-treated mice (right). Figures were taken at 400X magnification.

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
3.
Figure 1

Figure 1. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Expression of PE38 packaged in vitro in four cell lines. Cells were transduced with a full reaction of PE38 plasmid DNA packaged in vitro (solid lines), and the number of cells was compared to mock transduced cells (dashed lines). Cells were counted every other day in order to monitor their viability. Cell lines were: HeLa cells (a), KB-3-1 cells (b), K562 human erythroleukemia cells (c), and .45 human lymphoblastoid cells (d).

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
4.
Figure 7

Figure 7. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Tumor size and weight of mice treated with a combination of PE38 packaged in vitro and doxorubicin via IP. Treatment was followed three days after inoculation of mice with 2 × 106 KB-3-1 cells. Tumor size as well as the weight of the mice were followed for 56 days. Figure 6a demonstrates average tumor size in mm3 of IVP-PE-treated mice (blue), doxorubicin-treated mice (orange), and the combined treatment of IVP-PE38 with 5 mg/kg doxorubicin-treated mice (green) (five mice in each group). Panel b is the average weight of each of these groups with standard deviations (z = (−1.8991), one sided p-value = 0.0288 on day 40 of treatment with doxorubicin in comparison to the combination of doxorubicin and IVP-PE38)

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
5.
Figure 3

Figure 3. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Tumor size and weight of PE38 packaged in vitro and control mice treated subcutaneously several days post tumor challenge. Treatment was followed six days after mice were injected with 2 × 106 KB-3-1 cells. Tumor size as well as mouse weight were followed for 21 days. Figure 3 (a-c) demonstrates tumor size in mm3 of empty vector-treated mice (panel a) or IVP-PE38 (panel b) (five mice in each group, each line represents one mouse), and panel c is the average of each five mice (IVP-PE is shown in dark blue, and control-treated mice in magenta) with standard deviation. Figure 3 (d-f) demonstrates the weight in grams for these groups in this order (panels d, e, and f respectively).

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
6.
Figure 4

Figure 4. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Tumor size and weight of PE38 packaged in vitro and control mice treated intraperitoneally several days post tumor challenge. Treatment was followed three days after mice were inoculated with 2 × 106 KB-3-1 cells. Tumor size as well as mouse weight were followed for 34 days. Figure 4 (a-c) demonstrates tumor size in mm3 of PBS-treated mice (panel a) or IVP-PE38 (panel b) (five mice in each group, each line represents one mouse), and panel c is the average of each five mice (IVP-PE is shown in dark blue, and control-treated mice in magenta) with standard deviation (z = 1.7975, one sided p-value = 0.0361 for day 25 of treatment). Figure 4 (d-f) demonstrates the weight in grams for these groups in this order (panels d, e, and f respectively) (z = 2.0153, one sided p-value = 0.0219 for day 34 of treatment).

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.
7.
Figure 2

Figure 2. From: SV40 Pseudovirion Gene Delivery of a Toxin to Treat Human Adenocarcinomas in Mice.

Tumor size and weight of PE38 packaged in vitro and control mice treated from the day of tumor challenge. Mice were injected with 2 × 106 KB-3-1 cells along with the treatment. Tumor size as well as mouse weight were followed for 30 days. Figure 2 (a-c) demonstrates tumor size in mm3 of empty vector-treated mice (panel a) or IVP-PE38 (panel b) (five mice in each group, each line represents one mouse), and panel c is the average of each five mice (IVP-PE is shown in dark blue, and control-treated mice in magenta) with standard deviation (z = (−2.6191), one sided p-value=0.004 for day 25 of treatment). Figure 2 (d-f) demonstrates the weight in grams for these groups in this order (z = (−2.252), one sided p-value = 0.0122 for day 30 of treatment, z = (−1.744), one sided p-value = 0.0406 for relative weight gain by day 30 of treatment (wts on day 30/wts on day 4) (panels d, e, and f respectively).

Chava Kimchi-Sarfaty, et al. Cancer Gene Ther. ;13(7):648-657.

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