Figure 1

Figure 1. From: Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis?.

Mechanistic link of anoikis resistance to tumor cell metastasis. Two important cellular processes coordinate this cellular “connection”: EMT and reactive stroma formation. Caveolin-1, Galectin-3, and TrkB emerge as the critical contributors to apoptosis resistance, angiogenesis, and tumor cell migration. In this schematic diagram, these molecules are identified in the context of their contribution to the cellular connection driving the EMT and reactive stroma.

Gabriela Rennebeck, et al. Cancer Res. ;65(24):11230-11235.

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