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1.
Figure 1

Figure 1. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

Venn diagram of co-morbid, overlapping syndromes. The numbers of subjects satisfying the case designation criteria for CFS, PGI and FM in the Cohort 1 pooled CFS and pooled PGI groups, and Cohort 2 CFS group are shown. Each group had a highly unique combination of these syndromes.

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
2.
Figure 4

Figure 4. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

Ceruloplasmin (ferroxidase II) peptide mass spectrogram. This sequencing data was shown for the time-of-flight mass spectrometer (ToF, 2nd MS). The relative signal intensities for each fragment of the ceruloplasmin peptide (y-axis) were plotted against mass/charge (m/z; x-axis). The peptide, GVYSSDVFDIFPGTYQTLEMFPR, was sequenced from the y-series (right to left; N-terminal to C-terminal). It had m/z = 890.41 and z = 3+, for a mass of 2671.23.

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
3.
Figure 3

Figure 3. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

Multidimensional fatigue inventory scores (mean ± 95% C.I.). The healthy control (HC) pooled group (yellow bars) and individuals (beige bars) had lower scores for all categories than the pooled CFS (light blue bars), pooled PGI (light purple bars), and CFS individuals (teal bars) (p < 0.03 by ANOVA). The categories, from left to right, were general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue.

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
4.
Figure 5

Figure 5. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

The correlation between the frequencies of protein detection in the CFS (black triangles) and HC (open circles) groups were shown. Nineteen proteins were detected significantly more frequently in the CFS than HC group (p ≤ 0.05 by ANOVA). These CFS – associated proteins were shifted away from the line of identity. This line demonstrated the high correlation of detection frequencies between the CFS and HC samples for the remaining 98 proteins (R2 = 0.70).

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
5.
Figure 7

Figure 7. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

Isoelectric point (pI) vs. logarithm of molecular weight. The frequencies of detection for proteins in the healthy control (HC) group were graded as 1 to 25% (small circles), 26 to 50% and 51 to 100% (large circles). Proteins detected in the CFS group (open squares) were similarly graded. The CFS – associated proteins detected in 26 to 50% and 51 to 100% of samples were depicted as smaller and larger grey squares, respectively.

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
6.
Figure 2

Figure 2. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

SF-36 scores for each group (mean ± 95% C.I.). Physical Function (PF), Social Function (SF), Role Physical (RP), Role Emotional (RE), Mental Health (MH), Vitality (Vit), Pain, General Health Perception (GH-P) and General Health Change (GHΔ) were identical for the set of pooled (Cohort 1; yellow bars) and individual (Cohort 2; beige bars) HC subjects. These domains were also identical for the set of pooled CFS (light blue bars), pooled PGI (light purple bars) and CFS individuals (teal bars). Significant differences between these datasets were found for all indicators except RE, MH and GPΔ (p < 0.02 by ANOVA).

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.
7.
Figure 6

Figure 6. From: A chronic fatigue syndrome – related proteome in human cerebrospinal fluid.

Distributions of proteins in healthy control (HC) and CFS samples. The frequency of detection for each protein was determined for the HC (left axis) and CFS (right axis) groups. These axes were divided into "bins" of 0% (absent), 1 to 15%, 16 to 30%, 31 to 45%, 46 to 60%, 61 to 75%, and 76 to 100%. The vertical axis was the percentage of all proteins detected within each intersection of the CFS vs. HC matrix. Most of the proteins were detected in less than 30% of each group. Proteins detected in both groups with roughly equal frequencies of detection were near the line of identity (white bars). The grid region corresponding to the CFS – associated proteome was highlighted by black bars.

James N Baraniuk, et al. BMC Neurol. 2005;5:22-22.

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